摘要
目的分析非小细胞肺癌（NSCLC）患者的临床和病理特征、围术期血清内皮抑素和表皮生长因子受体（EGFR）水平对患者生存的影响。方法收集2008年1月至12月在上海交通大学附属第六人民医院胸外科接受手术治疗的50例NSCLC患者，从术后开始随访至2014年1月，平均随涝时间为36．44个月。采用多因素回归分析方法分析50例NSCI。C患者生存的相关因素。结果50例NSCLC患者的5年生存率为53．7％，中位生存期为50．6个月。肿瘤最大径〈3．5cm的患者生存率显著优于肿瘤最大径≥3．5cm的患者（χ2=8．086，P=0．004）；肺腺癌患者的生存率显著优于肺鳞癌患者（χ2=7．527，P=0．006）；术后病理分期I期的患者生存率显著优于Ⅱ和Ⅲ期患者（χ2=4．681，P=0．03；χ2=7．990，P=0．005）；术前内皮抑素水平〈20．4ng／ml的患者生存率显著优于内皮抑索水平≥20．4ng／ml的患者（χ2=5．213，P=0．022）；术后EGFR水平≥44．7pg／ml的患者生存率显著优于EGFR水平〈44．7pg／ml的患者（χ2=13．908，P=0．000），差异均有统计学意义。多因素回归分析显示术后EGFR水平是影响预后的独立因素（P=0．000）。结论术前内皮抑素水平低的患者和术后EGFR水平高的患者具有更好的生存优势。
Objective To investigate the influence of clinicopathological characteristics, endostain and epithelial growth factor receptor （EGFR） on the survival of the perioperative non-small cell lung cancer（NSCLC）. Methods Fifty patients with NSCLC undergoing surgical treatment in the Department of Cardiothoracic Surgery in Shanghai Sixth People＇s Hospital affiliated to Shanghai Jiao Tong University between January 2008 and December 2008 were collected, and were followed up after surgery till January 2014, with the mean time of follow-up of 36.44 months. The survival-related factors for these 50 patients with NSCLC were analyzed using multivariate regression analysis. Results The 5-year survival was 53.7% and the median survival time was 50.6 months for these 50 patients with NSCLC. The survival in patients with tumor maximum dimmer 〈3.5 cm was significantly bigger than that in those with tumor maximum dimmer ≥3.5 cm（χ2=8. 086, P = 0. 004）. The survival in patients with adenocarcinoma was significantly bigger than that in those with squamous carcinoma （χ2=7. 527, P= 0.006）. The survival in patients with stage I NSCLC was significantly bigger than those in patients with stage 1] and stage I]] NSCLC （ 2 = 4. 681, P = 0.03 ; χ2=7. 990, P = 0. 005）. The survival in patients with endostatin 20.4 ng/mL before operation was significantly bigger than that in those with endostatin20.4 ng/mL before operation（χ2= 5. 213, P= 0. 022）. The survival in patients with EGFR≥44.7 pg/mL after operation was significantly bigger than that in those with EGFR〈44.7 pg/mL after operation （χ2= 13. 908, P=0. 000）. Multivariate regression analysis indicated that EGFR after operation was an independent prognostic factor（P=0. 000）. Conclusion The patients with low level of endostain before operation and high level of EGFR after operation may gain bettor survival.
出处
《中华胸部外科电子杂志》
2015年第2期98-104,共7页
CHINESE JOURNAL OF THORACIC SURGERY：Electronic Edition
基金
上海市卫生局科研计划资助项目(2009088)
关键词
非小细胞肺
癌
内皮抑素
表皮生长因子受体
存活率
预后
随访研究
Non-small cell lung, cancer
Endostain
Epithelial growth factor receptor
Survival rate
Prognosis
Follow-up studies
