摘要
目的探讨大肠癌患者血清血管内皮生长因子(sVEGF)和血清内皮抑素的水平。方法应用酶联免疫吸附试验检测32例大肠癌患者和28例对照组的sVEGF、血清内皮抑素水平,分析二者的相关性及与临床病理学因素的关系。结果大肠癌患者sVEGF和血清内皮抑素水平呈正相关关系(P<0.01);大肠癌患者sVEGF和血清内皮抑素水平均显著高于对照组(P<0.01);sVEGF、血清内皮抑素与患者的性别、年龄、肿瘤部位、肿瘤分化程度和肿瘤直径大小无关,与淋巴结转移和Dukes分期相关。结论大肠癌患者的sVEGF和血清内皮抑素水平明显升高,二者可能共同调控肿瘤新生血管生成。
Objective To evaluate the levels and clinical significance of serum vascular endothelial growth factor（sVEGF） and serum endostatin（s-endostatin） in patients with colorectal cancer. Methods Enzyme-linked immunoabsorbent assay （ELISA） was used to detect preoperative sVEGF and s-endostatin in 32 patients with colorectal cancer and 28 volunteer blood donors. Results Positive correlation was detected between sVEGF and s-endostatin in patients with colorectal cancer. Preoperative levels of sVEGF and s-endostatin were markedly elevated in patients compared with controls（P 〈0.01）. No signigicant associations between sVEGF, s-endostatin and patient sex,age,tumor position,tumor size,histologic type were observed. Signigicant correlation was found between sVEGF, s-endostatin and lymph node metastasis, Duke＇s stage （P〈0.01）. Conclusion sVEGF and s-endostatin are elevated in patients with colorectal cancer, and the coupling between sVEGF and s-endostatin may control the tumor angiogenesis.
出处
《肿瘤研究与临床》
CAS
2006年第2期90-91,共2页
Cancer Research and Clinic
关键词
大肠癌
血管内皮生长因子
内皮抑素
Vascular endothelial growth factor
Endostatin
Colorectal cancer
