摘要
目的:探讨伴有和不伴有过敏性鼻炎慢性鼻-鼻窦炎的临床资料的区别,发现过敏性鼻炎对慢性鼻-鼻窦炎的影响,从而提高慢性鼻-鼻窦炎的治疗效果。方法:选取我院2012年2月至2014年10月138位慢性鼻-鼻窦炎患者,分为伴有过敏性鼻炎组和不伴有过敏性鼻炎组,记录患者一般临床资料,采用Visual analog scale(VAS,视觉类比评分)记录患者主观症状评分;Lanza-Kennedy法记录鼻内镜评分,Lund-Mackay法记录CT评分;抽外周血查血常规;最后比较两组之间指标的差异。结果:138例慢性鼻-鼻窦炎患者中,有36(26.2%)名患者合并过敏性鼻炎;伴有过敏性鼻炎的慢性鼻-鼻窦炎患者组中有52.78%的患者有变应性体质,22.2%的患者有哮喘病史;而不伴有过敏性鼻炎的慢性鼻-鼻窦炎组有21.57%的患者有变应性体质,3.9%的患者有哮喘病史,差异具有统计学意义(P值均≤0.001);伴有过敏性鼻炎慢性鼻-鼻窦炎组总VAS评分、鼻塞和流鼻涕症状评分明显高于不伴有过敏性鼻炎慢性鼻-鼻窦炎组,两组评分差异具有统计学意义(P值均<0.05);在血常规检查中发现,外周血白细胞、中性粒细胞、嗜酸粒细胞和单核细胞在伴有过敏性鼻炎的慢性鼻-鼻窦炎组中显著增加,其检测结果与不伴过敏性鼻炎组的差异具有统计学意义(P值均≤0.001)。结论:过敏性鼻炎的慢性鼻-鼻窦炎患者相对于不伴有过敏性鼻炎的慢性鼻-鼻窦炎患者有更多的变应性体质和哮喘病史;鼻塞和流鼻涕的的症状更重;对于这部分病人应该给予更充分的认识和抗过敏的针对性药物以及手术治疗,使患者的生活质量得到更好的改善。血常规可帮助诊断。
Objective： This study was designed to investigate the difference of clinical data between chronic rhinosinusitis（CRS）with and without allergic rhinitis（AR） and try to find the impact of AR to CRS, thereby enhancing the therapeutic effect of CRS.Methods： Select 138 CRS patients from Tongji hospital from February 2012 to October 2014 and divided into with AR group and without AR group, clinical data were collected： subjective symptom scores were recorded by Visual analog scale（VAS, visual analog scale）;endoscopic scores were recorded by Lanza-kennedy method; CT scores were recorded by Lund-Kennedy method; blood routine test were checked. The differences between two groups were compared. Results： Among 138 cases of CRS, 36（26.2%） were patients with AR;52.78% of these patients have atopy and 22.2% have a history of asthma; 21.57% of the CRS patients with AR have atopy and 3.9% of these patients have a history of asthma, the differences were statistically significant（P≤0.001）; The total VAS score, nasal obstruction score and nasal discharge score were higher in CRS with AR group than in CRS without AR group, the differences were statistically significant（P〈0.05）. The blood routine test shows that leukocyte, neutrophils, eosinophils and monocytes are significantly increased in with AR group than in CRS without AR group, the difference were statistically significant（P≤0.001）. Conclusions： The CRS patients with AR have heavier symptoms of nasal congestion and nasal discharge; blood routine test can help diagnose.
出处
《现代生物医学进展》
CAS
2015年第25期4875-4878,共4页
Progress in Modern Biomedicine
基金
国家自然科学基金项目(81470677)
