摘要
再生障碍性贫血（aplastic anemia，AA）是儿科较为常见的骨髓衰竭性疾病，临床上主要表现为骨髓造血功能低下、全血细胞减少以及贫血、出血、感染。其发病机制目前尚未完全阐明，越来越多的研究认为从的发病与免疫学机制的紊乱有关，主要包括T细胞亚群的异常、负调控因子水平的改变、体液免疫异常及细胞凋亡等。该文就AA的免疫学发病机制的研究进展作一综述。
Aplastic anemia is a more common pediatrics marrow failure disease. The main clinical mani- festations are bone marrow dysfunction, pancytopenia, anemia, bleeding and infection. Althrough its pathogenesis has not been fully elucidated so far,more and more people think that it is associated with the disorder of immunologiced mechanisms,including the abnormalities of T cells, the level of negative regttlator, humored immune abnormalities and apoptosis. This review discusses the progress of immunological mechanism of aplastic anemia.
出处
《国际儿科学杂志》
2015年第5期503-506,共4页
International Journal of Pediatrics
关键词
再生障碍性贫血
免疫机制
儿童
Aplastic anemia
Immunological mechanism
Children
