摘要
系统评价灯盏细辛注射液佐治冠心病心绞痛的疗效及安全性。计算机检索Cochrane图书馆,Medline,EMbase,CBM,CNKI,VIP和万方数据库中关于灯盏细辛注射液联合西医常规对冠心病心绞痛治疗的随机对照试验。根据Cochrane Reviewer's Handbook 5.1评价标准和工具评价纳入文献质量,用Rev Man 5.2软件进行Meta分析。该研究共纳入30个随机对照试验,总样本数为3 086例,试验组1 572例和对照组1 514例。Meta分析结果显示,灯盏细辛注射液佐治冠心病心绞痛与西医常规治疗相比能够减少心血管事件的发生(OR=0.33;95%CI:[0.16,0.67];P=0.002);灯盏细辛注射液佐治冠心病心绞痛有效率(OR=3.97;95%CI:[3.15,5.02];P<0.000 01)和心电图疗效(OR=2.21;95%CI:[1.83,2.68];P<0.000 01)优于西医常规治疗。漏斗图有一定的不对称,预示可能存在发表偏倚。现有证据表明,灯盏细辛注射液联合常规疗法治疗冠心病心绞痛在临床疗效及心电图改善等方面比单用西医常规疗效较好。但基于研究的局限,所获得的支持证据强度有待提升,且需设计严谨、随访时间更长的临床研究加以证实。
The paper is to systematically evaluate the efficacy and safety of Deng Zhan Xi Xin injection （DZXXI） as an adjuvant treatment for patients with angina pectoris. The Cochrane Library, Medline, EMbase, CBM, CNKI, VIP, and Wan fang Data base were searched. Randomized controlled trials （RCTs） of DZXXI combined with western medicine routine treatment versus western medi- cine routine treatment alone for angina pectoris patients were all included. All trials were assessed according to the Cochrane Reviewer＇ s Handbook 5.1 for Systematic Reviews of Intervention and Meta analyses were performed by RevMan 5.2 Software. A total of 30RCTs （3 086 patients including 1 572 patients of treatment group and 1 514 patients of control group） were included. Meta-analysis of treat- ment group compared with control group showed superior effect over reducing cardiovascular events （OR = 0. 33; 95% CI： [ 0. 16,0.67] ,P = 0. 002 ）, improving effective rate of DZXXI as adjuvant treatment for angina peetoris patients （OR = 3.97; 95% CI： [ 3.15,5.02 ] ; P 〈 0. 000 01 ） and electrocardiogram curative effect （ OR = 2. 21 ; 95 % CI ： [ 1.83,2. 68 ] ; P 〈 0. 000 01 ）. Funnel fig- ure seemed that there was publication bias. The current limited evidence showed that when compared with the control group, treatment group was superior in improving patients with angina pectoris. But based on the limitations of the study, rigorous design with long follow up clinical trims are necessary for further evidence.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2015年第16期3298-3307,共10页
China Journal of Chinese Materia Medica
基金
中央级公益性科研院所基本业务费项目(Z0406
PY1303)
2014年第七批博士后特别项目(2014T70202)
