摘要
目的：探讨同型半胱氨酸（ Hcy）、血脂[总胆固醇（ TC）、甘油三酯（ TG）、低密度脂蛋白胆固醇（ LDL-C）]联合检测在突发感音神经性耳聋（ SSHL）诊断中的意义。方法收集SSHL患者80例，以78名性别、年龄、种族相匹配的正常听力的人群作为正常对照组，分别检测2组血清Hcy、TC、TG和LDL-C浓度，分析其与SSHL的关系。结果 SSHL组血清Hcy、TC、TG、LDL-C浓度分别为（16．16±3．94）μmol／L、（5．38±0．99） mmol／L、1．66（1．23～5．70）mmol／L、（3．49±0．78） mmol／L，均明显高于正常对照组[（12．59±2．24）μmol／L、（4．51±0．91）mmol／L、1．48（0．69～3．01）mmol／L、（2．59±0．80）mmol／L]（P均＜0．01）。相关分析发现Hcy与TC、TG、LDL-C呈正相关（r值分别为0．669、0．514、0．704，P均＜0．01）。 Logistic回归分析显示Hcy及LDL-C是SSHL的重要风险因素[OR值（95％可信区间）分别为1．850（1．256～2．725）、4．412（1．134～17．170）]。 SSHL组中Hcy、LDL-C的阳性检出率分别为47．5％和51．3％，明显高于正常对照组（9．0％、14．1％，P均＜0．01）。联合检测Hcy及LDL-C的阳性率可达66．3％，高于单项检测的阳性率。结论联合检测血清Hcy和血脂在SSHL预防、临床筛检和风险评估中均具有一定的价值。
Objective To study the significance of homocysteine（ Hcy） and blood lipid detection [ total cholesterol （TC）, triglyceride（TG） and low-density lipoprotein cholesterol（LDL-C）] in the diagnosis of sudden sensorineural hearing loss（ SSHL） .Methods A total of 80 patients with SSHL were enrolled, and 78 subjects without SSHL matched with SSHL group for sex, age and race were enrolled as control group.The serum levels of Hcy, TC, TG and LDL-C were detected.The relationship with SSHL was analyzed.Results The serum Hcy, TC, TG and LDL-C levels in SSHL group [（16.16 ±3.94） μmol/L, （5.38 ±0.99）mmol/L, 1.66（1.23-5.70）mmol/L and （3.49 ±0.78）mmol/L] were significantly higher than those in control group [（12.59 ±2.24）μmol/L, （4.51 ±0.91）mmol/L, 1.48（0.69-3.01）mmol/L and （2.59 ±0.80）mmol/L] （P〈0.01）.The correlation analysis showed that serum Hcy was positively correlated with TC, TG and LDL-C（r=0.669, 0.514 and 0.704, P〈0.01）.Logistic regression analysis showed that Hcy and LDL-C were important risk factors for SSHL[OR（95% confidence interval） were 1.85（1.256-2.725） and 4.412（1.134-17.170）].The positive rates of Hcy and LDL-C were 47.5%and 51.3%in SSHL group and 9.0%and 14.1%in control group （P〈0.01）.The positive rate of the combined detection of Hcy and LDL-C was 66.3%, which was higher than any single-positive rate.Conclusions The combined detection of Hcy and blood lipid for SSHL has significance in preventing,diagnosing and risking assessment .
出处
《检验医学》
CAS
2015年第9期906-910,共5页
Laboratory Medicine
关键词
同型半胱氨酸
胆固醇
低密度脂蛋白
突发性耳聋
Homocysteine
Cholesterol
Low-density lipoprotein cholesterol
Sudden sensorineural hearing loss
