摘要
目的探讨褪黑素对脑出血继发脑损伤患者血清丙二醛(malondialdehyde,MDA)、NF-κB、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)及β2-微球蛋白(β2-microglobulin,β2-MG)的影响。方法收集脑出血继发脑损伤患者90例,根据用药不同分为实验组和对照组,每组各45例。对照组手术清除血肿后给予常规治疗,实验组患者在此基础上给予褪黑素胶囊2粒(含褪黑素6 mg)口服,1次/天,连续治疗2周。对患者治疗前后血清MDA、NF-κB、TNF-α及β2-MG水平进行检测。结果与治疗前相比,治疗后2组患者MDA、NF-κB、TNF-α与β2-MG水平均显著下降(P<0.05),与对照组相比,实验组患者治疗后上述指标下降水平较显著(P<0.05)。结论褪黑素能够明显降低脑出血继发脑损伤患者血清MDA、NF-κB、TNF-α及β2-MG水平,修复脑损伤。
Objective To investigate the effect of melatonin on serum malondialdehyde （MDA）, NF-κB, tumor necrosis factor-α（TNF-α） andβ2-microglobulin （β2-MG） levels in secondary brain damage following intracerebral hemorrhage patients.Methods 90 patients secondary brain damage following intracerebral hemorrhage were divided into experimental group and control group, 45 cases in each group.The control group were given conventional treatment after surgical removal of hematoma, and the experimental group, on the basis of control group, were given melatonin capsule （6 mg melatonin） , orally, once a day, for 2 weeks treatment.The levels of MDA, NF-κB, TNF-αand β2-MG in patients’ serum were detected.Results The MDA, NF-κB, TNF-αand β2-MG levels after treatment significantly decreased compared with before treatment in two groups （all P〈0.05）, and the above indexes in experimental group significantly decreased compared with control group （ P 〈0.05 ）.Conclusion Melatonin can significantly reduce the levels of MDA, NF-κB, TNF-αand β2-MG levels in brain injury patients with cerebral hemorrhage, and repair brain damage, which has a guiding significance for clinical use.
出处
《中国生化药物杂志》
CAS
2015年第6期71-73,共3页
Chinese Journal of Biochemical Pharmaceutics
关键词
褪黑素
脑出血继发脑损伤
丙二醛
肿瘤坏死因子-α
Β2-微球蛋白
NF-κB
melatonin
secondary brain damage following intracerebral hemorrhage
malondialdehyde
NF-κB
tumor necrosis factor α
β2-microglobulin
