摘要
目的:研究神经节苷脂(GM)治疗急性脑出血的临床疗效及其对血清炎症因子(TNF-α、IL-1β、IL-6、IL-8、CRP)水平的影响。方法:将我院神经内科2012年6月至2015年6月期间收治的140例急性脑出血患者随机均分成2组。2组患者均接受急性脑出血的常规对症治疗,观察组患者在常规治疗的基础上使用神经节苷脂钠注射液。治疗30d后比较2组的临床疗效和治疗前后血清炎症因子表达水平的差值。结果:观察组的总有效率为88.57%,高于对照组的71.43%(P<0.05)。患者治疗前后血清炎症因子表达水平的差值观察组高于对照组(P<0.05)。结论:神经节苷脂在治疗各型急性脑出血方面有着较好的临床疗效,且可以显著降低血清中TNF-α、IL-1β、IL-6、IL-8、CRP等炎症因子的水平,从而有效地抑制炎症反应的发生发展,对脑出血后继发脑损伤起到了很好的保护作用。
[Objective]To study the clinical curative effect of GM on acute intracerebral hemorrhage and its influence on the levels of serum inflammatory cytokines（ TNF- α,IL- 1β,IL- 6,IL- 8,CRP）.[Method]140 patients with acute cerebral hemorrhage treated in our department of neurology from June 2012 to June 2015 were randomly divided into control group and observation group. All patients received conventional symptomatic treatment of acute cerebral hemorrhage,and the patients in observation group received ganglioside sodium injection on the basis of conventional therapy.The clinical curative effect and the levels of serum inflammatory cytokines of two groups were compared after 30 d.[Result]The total effective rate of the observation group was 88. 57%. It was significantly higher than of the control group（ P〈0. 05）. The levels of serum inflammatory cytokinesinobservation group was significantly higher than the control group（ P〈0. 05）. [Conclusion]GM has better clinical curative effect in treatment of acute cerebral hemorrhage. It can significantly reduce the levels of serum inflammatory cytokines（ TNF- α,IL- 1β,IL- 6,IL- 8,CRP）,and to inhibit the development of inflammatory responseeffectively,playing a protective role of secondary brain injury after cerebral hemorrhage. So,GM should be in widespread use in the future.
出处
《浙江医学教育》
2016年第3期57-59,共3页
Zhejiang Medical Education
关键词
神经节苷脂
急性脑出血
炎症因子
Ganglioside（GM）
acute intracerebral hemorrhage
inflammatory cytokines
