摘要
目的寻找急诊首次确诊2型糖尿病伴亚临床动脉硬化患者的危险因素，做好该病的早期预防和综合干预。方法选择2013年4月至2015年2月我院急诊首次确诊的300例2型糖尿病患者作为观察对象，采用无创性高分辨超声血管成像技术对全部观察对象的髂总动脉、颈总动脉和股动脉内中膜厚度和粥样硬化斑块进行筛查，分别比较2型糖尿病组患者和2型糖尿病伴亚临床动脉粥样硬化组患者的性别、年龄、体重、吸烟史、血压、血糖、糖化血红蛋白、甘油三酯等方面的差异，并采用Logistic回归分析对可疑危险因素进行多因素分析。结果300例糖尿病患者中，合并亚临床动脉粥样硬化者122例（40．67％），无动脉粥样硬化者178例（59．33％）。单因素分析结果显示，2型糖尿病伴亚临床动脉粥样硬化患者年龄、收缩压、空腹血糖、餐后2h血糖均高于无动脉粥样硬化的2型糖尿病患者，而糖化血红蛋白、高密度脂蛋白则低于无动脉粥样硬化的2型糖尿病患者，差异有统计学意义（P〈0．05）。多因素Logistic回归分析结果发现男性、吸烟、年龄增加、收缩压和餐后2h血糖增加是2型糖尿病合并亚临床动脉粥样硬化的主要危险因素。结论年龄增加、男性、吸烟、血糖及收缩压是独立的危险因素，从上述危险因素人手，加强对疾病危险因素的控制，减少暴露对防控糖尿病大血管事件具有重要影响。
Objective To investigate risk factorof newly diagnosed type 2 diabetemellitu（T2DM） with subclinical atherosclerosifoearly prevention and integrated intervention. Method300 caseof newly diagnosed T2DM in emergency departmenof ouhospital from April 2013 to February 2015 were selected, detected intima-medithicknes（IMT） of arteriiliaccommunis, artericaroticommunis, arterifemoraliand atherosclerotiplaque of all patientwith non-invasive high-resolution ultrasound vasculaimaging technology. Compared sex, age, weight, smoking history, blood pressure, blood sugar, glycosylated hemoglobin, triglycerideof T2DM patientwith and withousubclinical atherosclerosis. Indentified risk factorof newly diagnosed T2DM with subclinical atherosclerosiby Logistiregression analysis. ResultThere were 122 case（40.67%） of subclinical atherosclerosiin 300 caseof newly diagnosed T2DM. Univariate analysishowed thaage, SBP, fasting glucose, 2 houpostprandial blood glucose of T2DM patientwith subclinical atherosclerosiwere highethan those of T2DM patientwithousubclinical atherosclerosis, and glycosylated hemoglobin, HDL were lower, with statistically significandifference（P〈0.05）. Logistiregression analysishowed thamen, smoking, increasing age, SBP and increasing 2 houpostprandial blood glucose in T2DM patientwere majorisk factorof subclinical atherosclerosis. Conclusion Age, male gender, smoking, blood sugaand SBP were independenrisk factors. Ican conducsignificanimpacon the prevention and control of T2DM to strengthen the control abouabove disease risk factors.
出处
《国际医药卫生导报》
2015年第18期2723-2725,共3页
International Medicine and Health Guidance News
关键词
2型糖尿病
动脉硬化
危险因素
Type 2 diabetes mellitus
Atherosclerosis
Risk factor
