高盐饮食对血压正常者血浆单核趋化蛋白-1的影响被引量：1

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摘要目的：观察慢性盐负荷对血压正常个体体内单核趋化蛋白-1（MCP-1）的影响,探讨盐负荷诱发的炎症反应在高血压发生、发展中的作用。方法：选取30例年龄在16~60岁的血压正常者参与为期2周的慢性盐负荷试验,包括基线调查3d,低盐饮食（51.3mmol/d）、高盐饮食（307.8mmol/d）各7d。用ELISA法测定血浆MCP-1。结果：受试者在高盐饮食期血压均升高,同时高盐期MCP-1水平较低盐期显著增高（P〈0.01）。结论：高盐饮食可诱发正常受试者体内MCP-1水平升高,提示高盐可能通过介导体内炎症水平的升高进而发挥其对心血管系统的损害作用。

作者高卫华蔡琴王丹刘富强牟建军

机构地区西安市第一医院心内科西安交通大学医学院第一附属医院心内科

出处《陕西医学杂志》 CAS 2015年第8期1062-1063,共2页 Shaanxi Medical Journal

基金国家自然科学基金(81070218)

关键词血压单核细胞化学吸引蛋白质1 盐类

分类号 R544 [医药卫生—心血管疾病]

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参考文献6

1Angeli F,Reboldi G,Verdecchia P.Hypertansion,inflammation and atrial fibrillation[J].Hypertens,2014,32(3):480-483. 被引量：1
2Mogelvang R,Haahr-Pedersen S,Bjerre M,et al.Osteoprotegerin improves risk detection by traditional cardiovascular risk factors and hsCRP[J].Heart,2013,99(2):106-110. 被引量：1
3张长群,许骥,张娈和,岳洪峰,李新柱.原发性高血压患者血清高敏C反应蛋白、脂联素、一氧化氮和内皮素1水平的变化[J].中华高血压杂志,2014,22(11):1078-1080. 被引量：36
4Liu FQ,Mu JJ,Liu ZQ,et al.Endothelial dysfunction in normotensive salt-sensitive subjects[J].Journal of Human Hypertension,2012,26:247-252. 被引量：1
5Harrison DG,Guzik TJ,Lob HE,et al.Inflammation,Immunity,and Hypertension[J].Hypertension,2011,57:132-140. 被引量：1
6Chamarthi B,Williams GH,Ricchiuti V,et al.Inflammation and Hypertension:The Interplay of Interleukin-6,Dietary Sodium,and the Renin–Angiotensin System in Humans[J].American Journal of Hypertension,2011,24:1143-1148. 被引量：1

二级参考文献18

1姜芳,李拥军,张辉,杨蓉,刘素云,祖秀光,郝玉明.冠心病患者血浆脂联素与内皮素-1、一氧化氮、假血友病因子的相关性[J].临床荟萃,2007,22(13):935-937. 被引量：4
2Bonadei I, Vizzardi E, I:Aloia A, et al. Role of aliskiren on arte- rial stiffness and endothelial function in patients with primary hy- pertension[J]. J Clin Hypertens (Greenwich), 2014,16 ( 3 ) :202- 206. 被引量：1
3Ndisang JF, Vannacei A, Rastogi S. Oxidative stress and inflam mation in obesity, diabetes, hypertension, and related cardio- metabolic complications[J]. Oxid Med Cell Longev,2014:506-948. 被引量：1
4Angeli F, Reboldi G, Verdecchia P. Hypertension, inflammation and atrial fibrillation[J]. J Hypertens, 2014,32 (3) :480-483. 被引量：1
5De Ciuceis C, Rossini C, La Boria E, et al. Immune mechanisms in hypertension[J]. High Blood Press Cardiovasc Prev, 2014,21 (4) :227-234. 被引量：1
6Mogelvang R, Haahr-Pedersen S, Bjerre M, et al. Osteoprote gerin improves risk detection by traditional cardiovascular risk fac tors and hsCRP[J]. Heart,2013,99(2) :106 -110. 被引量：1
7Wu A, Zhang D, Gao Y, et al. The correlation between high- sensitivity C-reactive protein, matrix metallopeptidase 9, and tra- ditional Chinese medicine syndrome in patients with hypertension [J]. Evid Based Complement Alternat Med,2013:780937. 被引量：1
8Jinghua L, Tie Z, Ping W, et al. The relationship between serum sialic acid and high-sensitivity C-reactive protein with prehyper- tension[J]. Med Sci Monit, 2014,20 : 551 -555. 被引量：1
9Asferg CL, Andersen UB, Linneberg A, et al. Obese hyperten- sive men have plasma concentrations of C-reactive protein similar to that of obese normotensive men[J]. Am J Hypertens,2014,27 (10) : 1301-1307. 被引量：1
10Skoglund PH, Arpeghrd J, Ostergren J, et al. Amino-terminal pro-B-type natriuretic peptide and high-sensitivity C-reactive pro- tein but not cystatin C predict cardiovascular events in male pa- tients with peripheral artery disease independently of ambulatory pulse pressure[J]. Am J Hypertens,2014,27(3) :363 -371. 被引量：1