摘要
目的：研究急性脑梗死患者血清血小板白细胞聚集体含量及其与动脉粥样硬化的相关性。方法：选择2012年5月~2015年10月在我院就诊的急性脑梗死患者作为研究的脑梗死组,同期在我院体检的健康志愿者纳入研究的对照组,测定两组血清中血小板白细胞聚集体、蛋白酶、细胞因子的含量。结果：脑梗死组患者血清中血小板白细胞聚集体、血小板单核细胞聚集体、血小板粒细胞聚集体、血小板淋巴细胞聚集体的含量均显著高于对照组（P〈0.05）;易损斑块组和稳定斑块组患者血清中血小板白细胞聚集体、血小板单核细胞聚集体含量均高于无斑块组（P〈0.05）,易损斑块组患者血清中血小板白细胞聚集体、血小板单核细胞聚集体含量均高于稳定斑块组（P〈0.05）;易损斑块组、稳定斑块组、无斑块组患者血清中血小板粒细胞聚集体、血小板淋巴细胞聚集体的含量无显著性差异（P〉0.05）。血小板单核细胞聚集体含量越高,脑梗死组患者血清中基质金属蛋白酶7（MMP7）、MMP9、组织蛋白酶K（CatK）、单核细胞趋化蛋白1（MCP-1）、血管内皮细胞钙黏蛋白（VE-cadherin）、白细胞分化抗原40（CD40）、CD40配体（CD40L）、巨噬细胞趋化因子配体16（CXCL16）的含量越高,对氧磷酶1（PON1）和PON3的含量越低（P〈0.05）。结论：急性脑梗死患者的血清血小板白细胞聚集体含量显著升高,白细胞中的单核细胞与血小板所形成的聚集体与颈动脉斑块的形成以及性质的改变有关,而淋巴细胞、粒细胞与血小板所形成的聚集体不参与颈动脉斑块的形成以及性质的改变。
Objective： To study the platelet-leukocyte aggregation content in serum of patients with acute cerebral in- farction and its correlation with atherosclerosis. Methods： Patients with acute cerebral infarction treated in our hospital between May 2012 and October 2015 were selected as the cerebral infarction group of the study, and healthy volunteers receiving physi- cal examination in our hospital during the same period were selected as the control group of the study. The serum levels of platelet-leukocyte aggregation, proteases and cytokines were determined. Results： Platelet-leukocyte aggregation, platelet-mon- ocyte aggregation, platelet-granulocyte aggregation and platelet-lymphocyte aggregation content in serum of cerebral infarction group were significantly higher than those of control group~ platelet-leukocyte aggregation and platelet-monocyte aggregation content in serum of vulnerable plaque group and stable plaque group were higher than those of no plaque group, and platelet- leukocyte aggregation and platelet-monocyte aggregation content in serum of vulnerable plaque group were higher than those of stable plaque group~ platelet-granulocyte aggregation and platelet-lymphocyte aggregation content in serum were not signifi- cantly different among vulnerable plaque group, stable plaque group and no plaque group. The higher the platelet-monocyte ag- gregation content, the higher the MMP7, MMPg, CatK, MCP-1, VE-cadherin, CD40, CD40L and CXCL16 content, and the lower the PON1 and PON3 content in serum of cerebral infarction group. Conclusions： Platelet--leukocyte aggregation content significantly increases in serum of patients with acute cerebral infarction, aggregation formed by monocyte of leukocytes and platelet is associated with the carotid plaque formation and the change in nature, but the aggregation formed by lymphocyte and platelet as well as granulocyte and platelet are not involved in the carotid plaque formation and the change in nature.
出处
《海南医学院学报》
CAS
2016年第22期2665-2668,2672,共5页
Journal of Hainan Medical University
基金
陕西省教育厅科研项目(2010JK811)~~
关键词
急性脑梗死
血小板白细胞聚集体
颈动脉粥样硬化
蛋白酶
Acute cerebral infarction
Platelet-leukocyte aggregation
Carotid atherosclerosis
Protease
