摘要
目的：观察雌孕激素联合心理疏导的综合治疗对卵巢早衰的效果。方法选取2012年5月-2014年5月辽宁电力中心医院收治的卵巢早衰患者64例,将其随机分为单纯激素组和联合治疗组,每组各32例。单纯激素组患者给予戊酸雌二醇片（补佳乐）1 mg/d,持续服用22 d,服药第12天时联合口服地屈孕酮片10 mg/d服用至第22天,两药同时停用。患者应该在停药3-7 d月经来潮,月经第5天继续按上述方式服药。如果患者在第1个雌孕激素治疗周期停药后7d月经未转,再按照之前方法服药1个疗程,继续观察。联合治疗组患者在进行上述雌孕激素替代治疗的基础上同时进行心理疏导。停药1-2个月后,于月经第2-5天复查血清促卵泡生成素、雌二醇和黄体生成素。观察两组患者周期性月经出血、阴道干涩、潮热出汗、心悸等症状的改善情况。结果联合治疗组患者有效率（93.8%）较单纯激素组（75.0%）明显增高,差异有统计学意义（P〈0.05）；治疗后,两组患者周期性月经出血、阴道干涩、潮热出汗及烦躁失眠发生率均较治疗前明显改善,联合治疗组优于单纯激素组,差异均有统计学意义（P〈0.05或P〈0.01）；血清学检测结果显示,联合治疗组患者血清卵泡刺激素、黄体生成素、雌二醇水平恢复平稳,且患者的幸福感指数总分[（14.19±4.71）分]也高于单纯激素组[（10.13±4.90）分],差异有高度统计学意义（P〈0.01）。结论雌孕激素联合心理疏导的综合治疗方法服用方便,患者易于接受,同时卵巢早衰的治疗效果有所提高。此联合治疗方法不仅可减轻患者痛苦,同时提高了患者幸福感指数,改善了患者生活质量。
Objective To investigate the clinical effects of estrogen and progesterone combined psychological counseling for treatment of the premature ovarian failure. Methods 64 patients diagnosed as premature ovarian failure from May 2012 to May 2014 in Liaoning Electric Power Central Hospital were selected, they were divided into two groups randomly, with 32 cases in each groups. The estrogen-progesterone group was treated with pentanoic acid estradiol 1 mg/d continuously for 22 days, until the 12th days, progesterone 10 mg/d to 22 days was added, two medicines stopped at the same time. Menstrual cramped after 3-7 days stopping medicines, continued taking medicines according to the above methods at the 5th days. If patients didn＇t turn in the 7th days after discontinuation of treatment cycle, took medicines again according to the above medicine methods, until to observe. Combined treatment group： on the basis of estrogen progesterone therapy combined with psychological counseling. Withdrawal after 1-2 months, at 2-5 days in the period of menstrual cramps, serum FSH and LH, E2 were detected. Improve situation of periodic menstrual bleeding, vaginal dryness, hot flashes, sweating, palpitation and other symptoms of patients in the two groups was observed. Results The effecteive rate of combined treatment group （93.8%） significantly increased more than estrogen-progesterone group （75.0%）, the difference was statistically significant （P 〈 0.05）. After treatment, incidence of periodic menstrual bleeding, vaginal dryness, hot flashes, sweating and irritable insomnia of patients in two groups was obviously improved, and the combined treatment group was superior to estrogen-progesterone group, the differences were statistically significant （P〈 0.05 or P〈 0.01）. Serological test results showed that after the combination therapy, serum levels of FSH, LH, and E2 in patients was with right. At the same time, the total points of happiness index of patients in the combined treatment group [（14.19±4.71） sc
出处
《中国医药导报》
CAS
2015年第26期65-69,共5页
China Medical Herald
关键词
卵巢早衰
雌孕激素
心理疏导
性激素
Premature ovarian failure
Estrogen-progesterone
Psychological counseling
Sex hormone
