摘要
目的:探讨乳香提取物对大鼠乙酸胃溃疡β-catenin和Cyclin D1的影响。方法:用冰醋酸制备大鼠慢性胃溃疡模型,随机分为3组,分别灌服生理盐水、乳香提取物、奥美拉唑等。免疫组织化学方法检测30 d和60 d胃黏膜β-catenin和Cyclin D1的蛋白表达。结果:第30 d中药组、西药组β-catenin、Cyclin D1表达增强,与模型组比较,有显著性差异(P<0.05);第60 d模型组、中药组和西药组β-catenin表达均无显著性差异(P>0.05)。结论:乳香提取物能上调胃粘膜β-catenin、Cyclin D1的表达,加快细胞的增殖,而促进溃疡的愈合,可能是乳香"生肌"的作用机理之一。
Objective： To investigate the effect of frankincense extract on β-catenin and Cyclin D1 of gastric ulcer rats. Method： The rat model of chronic gastric ulcer was induced by acetic acid. And then,they were randomly divided into three groups,fed with normal saline,frankincense extracts and omeprazole respectively. On 30 d and 60 d,expressions of the gastric mucosa of β-catenin and Cyclin D1 protein were detected by immunohistochemical method. Result：On 30 d in Chinese medicine group and Western medicine group,the expressions of β-catenin and Cyclin enhanced D1 and compared with the model group,there was significant difference（P 〈0. 05）. On 60 day in model group,Chinese medicine group and Western medicine group,the β-catenin expression had no significant difference（P 〉0. 05）. Conclusion： Frankincense extract could improve the expression of gastric mucosa β-catenin and Cyclin D1,accelerate cell proliferation and promote ulcer healing,which may be one of the mechanisms of frankincense generating muscle.
出处
《中华中医药学刊》
CAS
北大核心
2015年第9期2163-2164,I0011,共3页
Chinese Archives of Traditional Chinese Medicine
基金
湖北省教育厅重点项目(D20112807)
湖北省卫生厅中西医结合项目(2012Z-B01)
