摘要
目的：探讨雷贝拉唑为主的四联疗法治疗复发性幽门螺杆菌（Hp）阳性胃溃疡患者的疗效，观察其对血清白细胞介素18（IL-18）和白细胞介素35（IL-35）的影响。方法选择180例复发性 Hp 阳性的胃溃疡患者，应用随机数字表法将其分为两组，对照组（90例）应用胶体果胶铋、阿莫西林、克拉霉素进行治疗，观察组（90例）在上述基础上加用雷贝拉唑进行治疗。治疗4周行胃镜检查。同时检测治疗前、后血清中IL-18和 IL-35的表达。结果两组治疗后显效率（86．67％比73．33％，χ2＝5．000，P ＝0．025）、炎性反应的阳性率（26．67％比51．11％，χ2＝11．314，P ＝0．008）、Hp 阳性率（16．67％比31．11％，χ2＝5．163，P ＝0．023）差异均有统计学意义。观察组治疗后血清中 IL-18的表达明显下降[（70．80±11．21）比（88．83±7．13），t ＝8.27，P ＝0．021]，对照组无明显变化[（85．62±10．84）比（87．64±9．28），t ＝0．78，P ＝0．451]。两组治疗前后血清中 IL-35水平差异均无统计学意义（P ＞0．05）。结论以雷贝拉唑为主的四联疗法治疗复发性 Hp 阳性胃溃疡的疗效明显，且能有效下调血清中 IL-18的表达。
Objective To investigate the effect and changes of IL -18 and IL -35 in patients with recurrent Hp positive gastric ulcer by treating with leibeirazole quadruple therapy.Methods 180 patients with recurrent Hp positive gastric ulcer were divided into two groups.The control group（90 cases）was applied amoxicillin,clarithromy-cin and colloidal bismuth pectin.The observation group was added leibeirazole.The effect and changes of IL -18 and IL -35 were observed before and after treatment in the two groups.Results The effective rate （86.67% vs. 73.33%,χ2 =5.000,P =0.025）,inflammatory reaction rate（26.67% vs.51.11%,χ2 =11.314,P =0.008）and Hp positive rate（16.67 % vs.31.11%,χ2 =5.163,P =0.023）were higher in the observation group than in the control group.Expression of IL -18 was decreased after treatment[（70.80 ±11.21）ng/L vs.（88.83 ±7.13）ng/L, t =8.27,P =0.0210]in the observation group,but no change in the control group[（85.62 ±10.84）ng/L vs. （87.64 ±9.28）ng/L,t =0.78,P =0.4512）.Expression of IL -35 didn＆#39;t change after treatment in the two group （P 〉0.05）.Conclusion Leibeirazole quadruple can increase the clinical effect,decrease the expression of IL -18 in patients with recurrent Hp positive gastric ulcer,it is worthy to be applied in clinical treatment.
出处
《中国基层医药》
CAS
2015年第16期2479-2482,共4页
Chinese Journal of Primary Medicine and Pharmacy
