摘要
目的探讨并分析埃索美拉唑、克拉霉素及阿莫西林克拉维酸钾分散片联合治疗方案对消化性溃疡及根除幽门螺旋杆菌的疗效。方法选取本院收治的幽门螺旋杆菌感染的消化性溃疡患者121例,将其随机分为治疗组61例和对照组60例,对照组采用埃索美拉唑、克拉霉素和阿莫西林治疗,治疗组在对照组基础上以阿莫西林克拉维酸钾分散片代替阿莫西林。结果对照组和治疗组的溃疡愈合总有效率分别为88.3%和98.4%,HP根除率分别为78.3%和91.8%,6个月内复发率分别为1.6%和13.3%,两组溃疡愈合情况、HP根除及复发情况比较,差异均有统计学意义(P<0.05,P<0.05,P<0.01)。对照组和治疗组不良反应发生率为18.0%和15.0%,两组不良反应发生率比较,差异无统计学意义(P<0.05)。结论阿莫西林克拉维酸钾联合治疗方案提高溃疡愈合率、HP根除率及降低复发率方面,效果优于阿莫西林联合方案治疗组,且不良反应发生率较低,是治疗HP相关消化性溃疡的较优三联用药方案。
Objective To investigate and analyze the efficacy of amoxicillin clavulanate potassium combination drug therapy on peptic ulcer and the eradication of H. pylori. Methods 121 patients with peptic ulcer were randomly divided into the treatment group（61 cases） and the control group （60 cases）, patients in the control group were treated with esomeprazole, clarithromycin and amoxicillin, while patients in the treatment group were treated with amoxicillin clavulanate potassium tablet instead of amoxicillin on basis of the control group. Results The efficiency of the control group and the treatment group were 88. 3% and 98. 4% respec- tively, the HP eradication rates were 78. 3 % and 91.8%, and the recurrence rate within 6 months, were 1.6% and 13.3% individually, there were statistically significant between the two group （ P 〈 0. 05, P 〈 0. 05, P 〈 0.01 ）. The incidences of adverse reaction of the control group and the treatment group were 18.0% and lfi. 0%, with no statistically significant （ P 〈 0.05）. Conclusion Compared with the combination regimen of amoxicillin, amoxicillin clavulanate potassium combination drug therapy is more effective in improving the heal- ing rate, HP eradication rat.e and reducing the relapse rate, with lower incidence of adverse reactions, which is a perfect regimen in treatment of HP related peptic ulcer.
出处
《中国实用医药》
2013年第5期31-32,共2页
China Practical Medicine
