摘要
近年来,细胞自噬在脊髓损伤中的研究逐渐成为热点,但脊髓损伤后早期自噬激活所起的作用尚有争议。其原因在于细胞自噬在脊髓损伤中的作用具有两面性:一方面自噬能诱导自噬性细胞死亡的发生并参与细胞凋亡的发生,另一方面自噬能促进受损变性蛋白的代谢以及抑制细胞凋亡。然而究其对脊髓损伤后修复的利弊作用,早期自噬激活的程度具有决定作用,脊髓损伤后适当地上调自噬水平可促进受损变性蛋白的代谢并抑制细胞凋亡,而过度激活自噬可能引发自噬性细胞死亡。
In recent years,the study of autophagy in spinal cord injury（SCI）gradually becomes the hot spot. However,the function of autophagy in the injured spinal cord is still controversial. In order to further understand the role of autophagy after SCI,we summarized the activation of autophagy,autophagic cell death,the relationship between autophagy and apoptosis,the function of autophagy in promoting the molecular metabolism and the role of autophagy after spinal cord injury. We concluded that the role of autophagy after SCI is a double edged sword. Upregulating the level of autophagy appropriately can promote damaged proteins metabolism and inhibit apoptosis,However,excessive activation of antophagy may induce autophagic cell dealth. So we consider that the proper regulation of autophagy will be a new target in the treatment of SCI.
出处
《中国骨伤》
CAS
2015年第8期695-698,共4页
China Journal of Orthopaedics and Traumatology
基金
国家自然科学基金(编号:81401871
81401162)
浙江省医药卫生科技项目(编号:2013KYA127)~~
关键词
脊髓损伤
细胞自噬
综述文献
Spinal cord injury
Autophagy
Review literature
