摘要
目的探讨孟鲁司特致不良反应发生情况及相关规律、特点,寻找风险因素,为临床合理用药提供参照。方法以"孟鲁司特"、"不良反应"、"致"为检索词,检索中国期刊网全文数据库(CNKI)、维普中文科技期刊数据库(VIP),按纳入与排除标准共纳入32篇文献,对文献资料进行统计与分析。结果儿童及老年患者发生率高,累及器官损害主要为神经及精神系统、皮肤及其附件、泌尿系统、胃肠系统、血液系统、肝脏及骨骼系统等。结论重视孟鲁司特引起的不良反应,关注临床超适应证使用,加强老年和儿童用药监测,防范不良反应发生,确保临床用药安全。
Objective Through investigating the characteristics and mechanism of adverse reactions induced by montelukast, to find its risk factors and provide technical support for safe and rational use of drugs in clinic. Methods Using ＇montelukast＇, ＇adverse reaction＇and ＇caused by＇, as key words to search and retrieve articles in the CNKI and VIP database. Thirty-two references which met the inclusion and exclusion criteria were extracted and analyzed. Results Children and old patients appear to have higher ADR occurrence rate by using montelukast. Systems and Organs mainly involved in adverse reactions are nervous system, skin and its appendages, urinary system, gastrointestinal system, blood system, liver and skeletal system damage, etc. Conclusion It is important to pay attention to the adverse reactions caused by montelukast, as well as the clinical use beyond indications, specially to strengthen post-marketing surveillance in old patients and children, in order to prevent adverse drug reactions and ensure the safe drug use in clinic.
出处
《中国药物警戒》
2015年第8期494-496,共3页
Chinese Journal of Pharmacovigilance
关键词
孟鲁司特
药品不良反应
文献分析
montelukast
adverse drug reactions
literature review
