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孟鲁司特钠片致大疱性表皮松解症 被引量:2

Epidermolysis bollosa due to montelukast sodium tablets
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摘要 1例71岁男性患者因支气管扩张伴哮喘口服孟鲁司特钠片10 mg,1次/晚。用药第4天出现皮肤瘙痒,第5天颈部和手腕处出现水疱,第11天四肢及躯干部皮肤出现散在清亮大水疱伴瘙痒,部分水疱融合成片。考虑为大疱性表皮松解症,可能与孟鲁司特钠有关。停用孟鲁司特钠片,给予曲安奈德益康唑乳膏外用、乳酸依沙吖啶溶液湿敷、盐酸西替利嗪分散片口服等抗过敏治疗。停药第3天患者颈部水疱消退,躯干及四肢水疱干瘪,原水疱处皮肤出现溃烂,无渗出液,无新发水疱。1周后水疱基本消退,部分水疱消退处皮肤出现脱屑。 A 71-year-old male patient received montelukast sodium tablets 10 mg every night because of bronchiectasis with asthma.On day 4 of the medication,he developed itchy skin.On day 5,he developed blisters on his neck and wrist skin.On day 11,he developed scattered blisters filled with clear fluid on his limbs and trunk skin and part of them fused into lamella.Epidermolysis bollosa and the relationship to montelukast sodium were considered.Montelukast sodium tablets were stopped and antianaphylactic treatments including external triamcinolone acetonide and econazole nitrate cream and ethacriding lactate acid solution and oral cetirizine hydrochloride dispersible tablets were given.On day 3 of montelukast withdrawal,the blisters subsided and shriveled on his neck skin and on his limbs and trunk skin,respectively.Ulceration appeared on the skin of those subsided or shriveled blisters but no exudate.No new blisters were found.A week later,the blisters subsided basically and desquamation occurred in the skin where some blisters subsided.
作者 刘莹 赵荣生 Liu Ying;Zhao Rongsheng(Department of Pharmacy,China-Japan Friendship Hospital,Beijing 100029,China;Department of Administration and Clinical Pharmacy,School of Pharmaceutical Sciences,Peking University,Beijing 100191,China;Department of Pharmacy,Peking University Third Hospital,Beijing 100191,China)
出处 《药物不良反应杂志》 CSCD 2019年第6期478-480,共3页 Adverse Drug Reactions Journal
关键词 白三烯拮抗剂 表皮松解 大疱性 孟鲁司特 Leukotriene antagonists Epidermolysis bullosa Montelukast
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