摘要
目的探讨表观扩散系数(ADC)在宫颈鳞癌影像诊断中的临床价值。方法回顾性分析经手术病理证实的22例宫颈鳞癌和22例正常子宫的磁共振扩散加权成像(DWI)图像并测量比较ADC值。两组ADC值进行独立样本t检验,并进行受试者工作特征(ROC)曲线分析,选取诊断宫颈鳞癌的ADC阈值,计算敏感性及特异性。结果宫颈鳞癌组的22处病灶平均ADC值为(0.880±0.216)×10-3mm2/s,对照组平均ADC值为(1.265±0.198)×10-3mm2/s,两者差异有统计学意义(P<0.01);ROC曲线线下面积为0.890(P<0.01)。以ADC值<1.000作为肿瘤的诊断标准,44例病灶诊断正确,2例假阴性,1例假阳性。诊断准确性为93.2%,敏感性和特异性分别为95.5%和90.9%。结论测量ADC值可有效地鉴别正常宫颈组织及宫颈鳞癌灶,常规MRI与DWI相结合对宫颈鳞癌的诊疗有重要临床意义。
Objective To investigate the clinical value of apparent diffusion coefficient（ ADC） value in cervical squamous cell carcinoma. Methods Retrospective analysis of diffusion weighted imaging（ DWI） of 22 cases with cervical squamous cell carcinoma and 22 cases with normal pelvic. We calculated and compared the ADC values ofthe two groups by independent samples t test. We analyzed receiver operating characteristic curve（ ROC） to select ADC threshold for diagnostic criteria of cervical squamous cell carcinoma,and calculated the sensitivity and specificity. Results There was statistically difference of ADC value between the two groups. The average ADC value was（ 0. 880 ± 0. 216） × 10- 3mm2/ s in cervical squamous cell carcinoma group and（ 1. 265 ± 0. 198） × 10- 3mm2/ s in control group（ P 〈 0. 01）. The area under the ROC curve was 0. 890,P 〈 0. 01. With ADC 〈 1. 000 as the diagnostic criteria in cervical squamous cell carcinoma,44 cases were correctly diagnosed,2 cases were false negatives,1 case was false positive. The diagnostic accuracy was 93. 2%,the sensitivity and specificity were 95. 5% and 90. 9%,respectively. Conclusion The ADC value could effectively identify normal cervical tissue and cervical squamous cell carcinoma. Conventional MRI combined with DWI have important clinical significance in diagnosis of cervical squamous cell carcinoma.
出处
《临床放射学杂志》
CSCD
北大核心
2015年第8期1253-1256,共4页
Journal of Clinical Radiology
基金
湖北省卫生厅科研一般项目资助(编号:QJX2012-30)
关键词
受试者工作特征曲线
宫颈癌
扩散加权成像
表观扩散系数
Receiver operating characteristic curve
Cervical cancer
Diffusion weighted imaging
Apparent diffusion coefficient
