摘要
目的分析3.0T磁共振动态增强(DCE-MRI)扫描定量参数对肺癌的诊断价值。方法对我院近两年(2016年1月至2018年1月)呼吸内科经病理证实为肺癌的89例患者均行磁共振(MRI)常规检查及DCE-MRI检查,比较不同类型肺癌及周围正常胸壁组织的各定量指标[容量运转参数(K^(trans))、速率常数(K_(ep))血管外细胞外容积比(V_e)],分析DCE-MRI不同定量参数对肺癌的诊断效能,并确定最佳阈值。结果 (1)病理结果显示89例肺癌患者中央型肺癌41例、周围型肺癌48例;鳞癌25例、腺癌49例、小细胞癌15例,所有患者均为单发病灶;(2)肺癌病灶定量参数K^(trans)、K_(ep)、V_e均显著高于周围正常胸壁组织(P<0.05),各癌灶各定量参数K^(trans)、K_(ep)、V_e差异显著(P<0.05),非小细胞肺癌(鳞癌及腺癌)定量参数均显著高于小细胞癌(P均<0.05),腺癌定量参数均显著高于鳞癌及小细胞癌(P<0.05)(3)定量参数K^(trans)、K_(ep)、V_e对肺癌的诊断具有较高的临床价值,ROC曲线下曲线下面积(AUC)分别为0.816、0.768、0.821,其敏感度分别为71.5%、68.7%、68.4%,特异度分别为85.2%、82.6%、97.2%。结论 3.0T磁共振动态增强扫描定量参数可较准确诊断肺癌并测定不同病理类型肺癌,具有较高的临床诊断价值,可为临床肺癌的诊断提供影像依据。
Objective To analyze the diagnostic value of quantitative parameters of 3.0 T dynamic contrast-enhancement magnetic resonance imaging(DCE-MRI) scanning for lung cancer. Methods A total of 89 patients which confirmed of lung cancer pathologically for the past two years(January 2016 to January 2018) were gin magnetic resonance imaging(MRI) routine examination and DCE-MRI. The quantitative indicators [capacity transfer constant(Ktrans), rate constant(Kep), extravascular extracellular volume ratio(Ve)]were compared among different types of lung cancer and surrounding normal chest wall tissue. And the diagnostic efficacy of different quantitative parameters of DCE-MRI for lung cancer was analyzed, and the optimal threshold was determined. Results The pathological results showed that there were 41 cases of central lung cancer, 48 cases of peripheral lung cancer, 25 cases of squamous cell carcinoma, 49 cases of adenocarcinoma and 15 cases of small cell carcinoma among 89 cases of patients with lung cancer, and all patients were single lesions. Quantitative parameters Ktrans, Kep and Ve of lung cancer lesions were significantly higher than those of surrounding normal chest wall tissue(P<0.05). There were significant differences in quantitative parameters Ktrans, Kep and Ve of each lesion(P<0.05), and the quantitative parameters of non-small cell lung cancer(squamous cell carcinoma and adenocarcinoma) were significantly higher than those of small cell carcinoma(all P<0.05), and the quantitative parameters of adenocarcinoma were significantly higher than those of squamous cell carcinoma and small cell carcinoma(P<0.05). Quantitative parameters Ktrans, Kep and Ve had high clinical value in the diagnosis of lung cancer, the areas under the ROC curve(AUC) were 0.816, 0.768 and0.821 respectively, and the sensitivities were 71.5%, 68.7%, and 68.4% respectively, and the specificities were 85.2%, 82.6%, and 97.2% respectively. Conclusion Quantitative parameters of 3.0 T dynamic contrast-enhancement magnetic resonance imaging scan
作者
王大勇
周青
方朋
赵盼雄
WANG Da-yong;ZHOU Qing;FANG Peng(Department of Image Center,the First Affiliated Hospital of Henan University,Kaifeng 475001,Henan Province,China)
出处
《中国CT和MRI杂志》
2019年第3期7-10,153,共5页
Chinese Journal of CT and MRI
基金
河南省卫生计生委科技攻关项目(编号:201504H012)
关键词
肺癌
病理类型
磁共振成像
动态增强扫描
诊断
Lung Cancer
Pathological Types
Magnetic Resonance Imaging
Dynamic Enhanced Scanning
Diagnosis
