摘要
目的利用3.0T磁共振弥散加权成像(DWI)进行子宫颈癌表观弥散系数(ADC)值与临床病理的相关研究。方法回顾性分析有完整盆腔MRI检查并经病理证实的51例子宫颈癌。采用两组随机对照t检验比较子宫颈癌与正常子宫颈、子宫颈癌不同病理类型的ADC值;采用方差分析比较不同分化程度的子宫颈鳞状细胞癌的ADC值。结果 (1)51例子宫颈癌与16例正常子宫颈的ADC值分别为(0.92±0.19)×10-3mm2/s和(1.26±0.24)×10-3mm2/s,两组差异有统计学意义(t=0.587,P<0.01)。(2)46例子宫颈鳞状细胞癌及5例非鳞状细胞癌的ADC值分别为(0.92±0.20)×10-3mm2/s和(0.89±0.11)×10-3mm2/s,两组差异无统计学意义(t=0.29,P=0.08)。(3)46例子宫颈鳞状细胞癌包括高分化5例、中分化19例及低分化22例,ADC值分别为(1.08±0.28)×10-3mm2/s、(0.85±0.14)×10-3mm2/s及(0.94±0.21)×10-3mm2/s,三组间差异有统计学意义(F=5.88,P=0.02)。结论 3.0TDWIADC值测量能够在一定程度上定量反映子宫颈癌的弥散受限情况。初步结果表明,子宫颈癌的不同病理类型、恶性程度与ADC值有一定相关性,但有待于加大样本量深入研究。
Objective To measure the apparent diffusion coefficient（ADC）value of diffusion weighted imaging（DWI）at 3.0 T magnetic resonance（MR）in cervical cancer and correlated with pathology.Methods This retrospective study included 51 patients with histologically proven cervical cancer who underwent MRI examination.ADC values were measured and analyzed between cervical cancer and normal cervix.The ADC values in different pathologic categories of cervical cancer,and different differentiation of squamous cancer were also compared.Results The ADC values in 51 patients of cervical cancer and normal cervix of 16 volunteers were（0.92±0.19）×10-3mm2/s and（1.26±0.24）×10-3mm2/s respectively,with statistically significant difference between two groups（t=0.587,P0.01）.The ADC value in 46 patients of squamous cancer and 4 patients of non-squamous cancer were（0.92±0.20）×10-3mm2/s and（0.89±0.11）×10-3mm2/s respectively,without statistically significant difference between these two kinds of cervical cancer（t=0.29,P=0.08）.The ADC value of 5 cases of well-differentiated,19 cases of moderately differentiated and 22 patients of poorly differentiated squamous cancer were（1.08±0.28）×10-3mm2/s,（0.85±0.14）×10-3mm2/s and（0.94±0.21）×10-3mm2/s respectively,with statistically significant difference between these three groups（F=5.88,P=0.02）.Conclusions The ADC value of the diffusion weighted 3.0 T MR imaging can reflect the diffusion limited of cervical cancer quantitatively.The initial study manifest that the ADC value has relevance to different pathologic categories and different differentiation of cervical cancers.But study of large sample is needed.
出处
《中华临床医师杂志（电子版）》
CAS
2011年第2期30-33,共4页
Chinese Journal of Clinicians(Electronic Edition)
基金
广东省科技计划项目(2008B080703018)
关键词
宫颈肿瘤
磁共振成像
弥散
肿瘤
组织学类型
Uterine cervical neoplasms
Diffusion magnetic resonance imaging
Neoplasms by histologic type
