摘要
目的:探讨复方甘草合剂/口服溶液致不良反应(ADR)的一般规律及特点,为临床合理用药提供参考。方法:检索1995-2014年中国期刊全文数据库和万方数据库中的复方甘草合剂/口服溶液致ADR报告文献,对收集到的27例ADR的相关情况进行分类、归纳、统计、分析。结果:27例ADR多见于中老年患者(18例,占66.66%);所有患者均为口服给药,其中9例用药剂量偏大;有12例存在联合用药情况;用药30 min以内和1 d后发生ADR的比例相当,均为29.63%;累及器官/系统主要是皮肤及其附件损害(27.59%)、循环系统损害(24.14%)、神经系统损害(19.54%)和全身性损害(14.94%);26例患者经停药或治疗后恢复正常,1例患者死亡。结论:应通过积极开展用药宣教、用药前仔细询问患者情况、严格选择用药人群和用药方法、加强用药监测和警示等途径,减少复方甘草合剂/口服溶液ADR的发生。
OBJECTIVE： To explore the general regularity and characteristics of adverse drug reactions （ADR） induced by Compound glycyrrhiza mixture/oral solution, and provide reference for clinical ration use of drug. METHODS： The literatures of ADR induced by Compound glycyrrhiza mixture/oral solution were retrieved in CJFD and Wanfang database from 1995 to 2014, and the collected 27 cases of ADR were classified, summarized and statistically analyzed. RESULTS： The 27 cases of ADR were more common in middle-aged and aged patients （18 cases, 66.66% ）; all patients were orally administrated, and 9 of them had relatively larger dose; there were 12 cases with combination medication; the proportion of the incidence of ADR within 30 min and after 1 d was similar, it was 29.63% ; involved organs/systems were mainly skin and its appendages （27.59%）, circulatory system damage （24.14%）, nervous system damage （19.54%） and systemic damage （14.94%） ; 26 patients were recoveried after drug withdrawal and treatment, one patient died. CONCLUSIONS ： The incidence of ADR of Compound glycyrrhiza mixture/oral solu- tion should be reduced by actively carrying out medication propaganda and education, carefully asking patients before treatment, strictly select medication groups and methods and strengthening medication monitoring and warning, etc.
出处
《中国药房》
CAS
北大核心
2015年第24期3361-3363,共3页
China Pharmacy
关键词
复方甘草合剂/口服溶液
不良反应
文献分析
Compound glycyrrhiza mixture/oral solution
Adverse drug reaction
Literature analysis
