摘要
目的:探讨吲哚美辛口服制剂所致不良反应的临床特征、相关因素,为合理用药提供参考。方法:检索中国生物医学文献数据库、中国期刊全文数据库及中文科技期刊全文数据库1994～2009年以来收载的关于吲哚美辛口服制剂不良反应的文献,并进行分析。结果:得到符合标准的病例137例,不良反应报告中男性多于女性;不良反应以消化系统损害最多(26例,18.98%),其次为全身性损害(24例,17.52%)、循环系统损害(19例,13.87%)、皮肤及附件损害(17例,12.40%);不良反应较为严重。结论:不良反应的发生受多种因素影响,应特别警惕患者发生消化道出血和休克。
OBJECTIVE： To analyze the clinical features and correlation factors of ADR caused by Indometacin oral preparation and to provide references for rational use of drugs.METHODS： Retrieved from CBM Database,CNKI and Chinese Periodical Fulltext Database,literatures on ADR caused by Indometacin oral preparation during 1994～2009 were analyzed.RESULTS： 137 ADR cases were enrolled.The number of male patients was more than female.Main manifestation of ADR were injury of digestive system（26 cases,18.98%）,followed by general impairment of body（124 cases,17.52%）,injurg of circulatory system（19 case,13.78%）and lesion of skin and its appendants（17 cases,12.40%）.The situation of ADR was severe relatively.CONCLUSION： The occurrence of ADR causes by many factors.We should pay attention to f hemorrhage of digestive tract and shock.
出处
《中国药房》
CAS
CSCD
北大核心
2010年第36期3435-3436,共2页
China Pharmacy
