摘要
目的探讨c-Jun蛋白在肝细胞癌（肝癌）中的表达及其与预后的关系。方法回顾性分析2010年1月至2013年12月在中山大学附属第三医院行肝切除术的137例肝癌患者临床资料。其中男112例,女25例;年龄26~73岁,中位年龄45岁。所有患者均签署知情同意书,符合医学伦理学规定。采用免疫组化法检测肝癌组织c-Jun蛋白表达。根据免疫组化法染色评分将患者分为高表达组（75例）和低表达组（62例）。分析两组患者临床病理学参数及c-Jun蛋白表达与生存预后的关系。两组患者临床病理学参数比较采用χ2检验,生存分析采用Kaplan-Meier法和Log-rank检验。结果肝癌c-Jun蛋白表达与患者HBs Ag、AFP、肿瘤直径、肿瘤包膜、肿瘤血管侵犯有关（χ2=5.27,32.68,4.86,1.04,4.62;P〈0.05）。高表达组患者3、5年累积生存率分别为64.14%、41.20%,低表达组相应为72.04%、61.21%,高表达组患者的总体生存率明显低于低表达组（χ2=5.19,P〈0.05）。结论 c-Jun蛋白可能在肝癌的发生、发展中起到重要作用,其高表达预示患者预后不良。
Objective To investigate the expression of c-Jun in hepatocellular carcinoma （HCC） and its correlation with prognosis. Methods Clinical data of 137 patients with HCC undergoing hepatectomy in the Third Affiliated Hospital of Sun Yat-sen University between Janunary 2010 and December 2013 were retrospectively studied. Among the 137 patients, 112 were males and 25 were females with the age ranging from 26 to 73 years old and the median of 45 years old. The informed consents of all patients were obtained and the local ethical committee approval had been received. The expression of c-Jun in HCC tissues was detected by immunohistochemistry. The patients were divided into the high-expression group （n=75） and low-expression group （n=62） according to the scores of immunohistochemical staining. The clinicopathological parameters and the correlation between c-Jun expression and prognosis of the two groups were analyzed. Comparison on clinicopathological parameters was conducted using Chi-square test and survival analysis was conducted using Kaplan-Meier and Log-rank test. Results The expression of c-Jun in HCC was correlated with HBsAg, alpha-fetoprotein （AFP）, tumor size, tumor capsule and tumor vascular invasion （x^2=5.27, 32.68, 4.86, 1.04, 4.62; P〈0.05）. The 3-, 5-year cumulative survival rate of the high-expression group was respectively 64.14% and 41.20% and those of the low-expression group was respectively 72.04% and 61.21%. The overall survival of the high-expression group was significantly lower than that of the low-expression group （x^2=5.19, P〈0.05）. Conclusion c-Jun may play an important role in the occurrence and development of HCC and high expression of c-Jun indicates poor prognosis.
出处
《中华肝脏外科手术学电子杂志》
CAS
2015年第4期250-253,共4页
Chinese Journal of Hepatic Surgery(Electronic Edition)
基金
广东省科技计划项目(2011B61300011)
关键词
癌
肝细胞
C-JUN
预后
Carcinoma, hepatocellular
c-Jun
Prognosis
