摘要
目的探讨癌基因产物c-jun在宫颈癌、宫颈癌前病变(CIN)以及宫颈炎症组织中的表达及临床意义。方法采用免疫组织化学S-P法检测23例宫颈癌、44例CIN及10例宫颈炎组织标本中c-jun蛋白的表达情况。结果c-jun蛋白在宫颈癌、CIN Ⅲ级、CIN Ⅱ级、CIN Ⅰ级以及宫颈炎中的阳性表达率分别为78.3%(18/23)、54.5%(6/11)、38.5%(5/13)、30.0%(6/20)、0(0/10);c-jun蛋白在宫颈癌、CIN和宫颈炎组织中的表达存在显著差异(P<0.05)。c-jun蛋白在CIN各级中的表达无显著差异(P>0.05)。结论c-jun蛋白的表达可能与宫颈癌前病变、宫颈癌的发生密切相关。
Objective To explore the clinical significance of the expression proto-oncogene c-jun in uterine cervix cancer, cervical intraepithelial neoplasias（CINs） and cervicitis. Methods Immunohistochemical method was performed to detect the ex- pression of c-jun oncoprotein in 23 invasive cervical carcinomas, 44CINs and 10 cervicitis in our department. Results The expression of c-jun in cervical invasive carcinoma, CIN Ⅰ , Ⅱ , Ⅲ and cervicitis respectively was 78. 3%（18/23）, 30. 0%（6/20）, 38. 5% （5/13）, 54. 5%（6/11）, 0.0% （0/10）. The expression of c-jun in invasive carcinoma was significantly higher than in CIN （P%0. 05）. The expression of c-jun in CIN was significantly higher than in cervicitis （P〈0. 05）. It was not evidently different in CIN Ⅰ s, CINⅡ s, CINⅢs（P〉0. 05）. Conclusion The overexpression of c-jun probably is closely related with the occurrence of cervical carcinoma and CIN.
出处
《华中医学杂志》
2007年第6期441-442,共2页
Central China Medical Journal
