摘要
目的：探讨不同水平的糖化血红蛋白（ HbA1c）对2型糖尿病（ T2DM）患者血管内皮和左心结构及功能的影响程度。方法入选115例2型糖尿病患者，根据测得糖化血红蛋白水平分为HbA1c＜7％组42例，HbA1c 7％-9％组42例，HbA1c＞9％组31例。同时入选82例健康志愿者作为正常对照组。应用外周动脉张力测定（ PAT）技术检测所有入选者血管内皮细胞功能、计算反应性充血指数（ RHI）。所有入选者均行超声心动图检查。结果①与正常对照组相比，HbA1c 7％-9％组和HbA1c＞9％组患者的RHI值存在明显减低（P＜0．05），且HbA1c＞9％组患者RHI最低（P＜0．05）；②与HbA1c＜7％组相比， HbA1c 7％-9％组和HbA1c＞9％组患者舒张末期左心室后壁厚度（ LVPW）、室间隔厚度（ IVS）、左心室舒张晚期峰值速度（ A）明显增加（P＜0．05），左心室舒张早期峰值流速（E）、E／A值明显降低（P＜0．05，P＜0．01）。结论糖化血红蛋白＞7％时，2型糖尿病患者的内皮功能、左心结构及功能均会出现异常，其异常程度随着糖化血红蛋白的升高而加重。
Objective To investigate the effects of the different glycated hemoglobin（ HbA1c） on the endothelial function and the left ventricular structure and function in type 2 diabetes mellitus（T2DM）.Methods A total of 115 cases patients with T2DM and 82 age and sex matched normal controls were enrolled in this study.They were divided into four groups：the control group of 82 cases, HbA1c〈7%group of 42 cases, HbA1c 7%-9%group of 42 cases, 31 cases of HbA1c〉9%group.The function of vascular endothelial cells was eraluated,and the reactive hyperemia index using PAT Technology （ RHI） .The left ventricular structure and function were evaluated ac-cording to the results of echocardiographic measurements.Results ①Compared with the control group,the RHI value of HbA1c 7%-9% group and HbA1c〉9%group,reduced （P〈0.05）, and the patients in the HbA1c〉9%group RHI was the lowest （P〈0.05）.②Left ventricular posterior wall thickness（LVPW） and interventricular septal thickness（IVS） of HbA1c 7%-9%group and HbA1c〉9%group were higher than HbA1c〈7%group（P〈0.05） ,meanwhile the ratio of E/A was much lower, especially in HbA1c〉9%group（P〈0.05 or P〈0.01）.Conclusion In T2DM patients with HbA1c〉7%, the endothelial function and the left ventricular structure and function were involved.With the increase of HbA1c, the impairments were more prominent.
出处
《医学研究杂志》
2015年第7期91-95,共5页
Journal of Medical Research
基金
首都市民健康基金资助项目(Z13110200400000)
关键词
2型糖尿病
糖化血红蛋白
内皮功能
左心结构与功能
Type 2 diabetes mellitus
HbAlc
Endothelial function
Left ventricular structure and function
