摘要
目的探讨尿微量蛋白/肌酐(A/C)比值对冠心病合并2型糖尿病(T2DM)患者心功能及糖、脂代谢的影响。方法选取2015年1月~2017年12月河北省哈励逊国际和平医院心内科收治的826例冠心病合并T2DM患者作为研究对象,按A/C比值分为A/C异常组(n=472)及A/C正常组(n=354)。比较两组患者的心功能参数、血糖与胰岛素抵抗指数(IR)、血脂水平。结果 A/C异常组患者的左心室射血分数(EF%)低于A/C正常组,差异有统计学意义(P<0.05),A/C异常组患者的左心室收缩末期内径(LVESD)及左心室舒张末期内径(LVEDD)高于A/C正常组,差异有统计学意义(P<0.05)。A/C异常组患者空腹血糖(FPG)、餐后2 h血糖(2 h PG)、IR、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)及小而密低密度脂蛋白胆固醇(sd LDL-C)高于A/C正常组,差异有统计学意义(P<0.05),总胆固醇(TC)低于A/C正常组,差异有统计学意义(P<0.05)。结论 A/C比值能够预测冠心病合并T2DM病患者糖、脂代谢水平及心功能状态。
Objective To investigate effect of urinary mieroprotein/ereatinine ratio （A/C） on cardiac function and glyeometabolism in patients with coronary heart disease complicated type 2 diabetes mellitus （T2DM）. Methods A total of 826 patients with coronary heart disease complicated T2DM form January 2015 to December 2017 were selected as subjects and were divided into A/C abnormal group （n=472） and A/C normal group （n=354） according to the A/C ratio. The differences of cardiac function parameters, blood glucose, insulin resistance index （IR） and blood lipid levels were contrasted between A/C abnormal group and A/C normal group,and correlation between A/C ratio and cardiac function parameters and glueofipid metabolism was analyzed. Results The left ventrieular ejection fraction （EF%） in the A/C abnormal group was lower than that in the A/C normal group, the difference was statistically significant （P〈0.05）.Left ventrieular end systolic diameter （LVESD） and left ventrieular end diastolic diameter （LVEDD） in the A/C abnormal group were higher than those in the A/C normal group, the differences were statistically significant （P〈0.05）. The fasting plasma glucose （FPG）, 2-hour postprandial blood glucose （2 h PG）, IR, triglyeeride （TO, low density fipoprotein cholesterol （LDL-C）, small dense low-density lipoprotein cholesterol （sd LDL-C） in the A/C abnormal group were higher than those in the A/C normal group, the differences were statistically significant （P〈0.05）. And level of total cholesterol （TC） in the A/C abnormal group was lower than that in the A/C normal group, the differences were statistically significant （P〈0.05）. Conclusion A/C ratio could predict level of glucose, lipid metabolism and cardiac function in patients with coronary heart disease complicated T2DM.
作者
张若兰
张丽艳
ZHANG Ruo-lan;ZHANG Li-yan(Department of Cardiology,Harrison International Heping Hospital,Hebei Province,Hengshui 053000,China;Department of Imaging,Second Affiliated Hospital of Hebei Medical University,Hebei Province,Sijiazhuang 050000,China)
出处
《中国当代医药》
2018年第28期45-47,51,共4页
China Modern Medicine
基金
河北省省级科技计划项目(152777200)
关键词
尿微量蛋白/肌酐比值
2型糖尿病
冠心病
脂代谢
糖代谢
心功能
Urinary mieroproteirdereatinine （A/C）
Type 2 diabetes mellitus
Coronary heart disease
Lipid metabolism
Carbohydrate metabolism
Cardiac function
