摘要
细菌耐药性问题已逐渐成为社会广泛关注的问题。然而,可运用于临床的新型抗生素却十分匮乏。这主要是因为细菌的耐药机制极其复杂,我们对细菌耐药机制的理解不够全面和深入。近几年,多种生物小分子被发现能够使细菌获得广谱的耐药性,并被证明是广泛存在于细菌中的一种耐药机制,这是对目前细菌耐药理论和模型的一个非常重要的补充,更有助于在抗生素的研发过程中寻找新的作用靶标。我们通过总结分析一氧化氮、硫化氢及吲哚这3种信号小分子与细菌耐药的相关研究进展,探讨信号小分子使细菌获得耐药性的相关机制。
The problem of bacterial resistance has become the social widespread concern.However,the new anti-biotics in the clinical application are very scarce.Our understanding of the mechanisms of bacterial resistance isnot comprehensive and in-depth enough mainly because they are very complicated.But in recent years,a varietyof small signaling molecule are found to make bacteria drug resistance against broad spectrum antibiotics which isshown to be widely existed in bacteria as a mechanism of resistance.It is a very important supplement to bacteri-al resistance theory and model at present,and more conducive to choose appropriate targets in the developmentprocess of new antibiotics.In this review,we summarized and analyzed the correlation and mechanism of bacterialresistance and small signaling molecule including nitric oxide,hydrogen sulfide and indole.
出处
《生物技术通讯》
CAS
2015年第4期570-573,578,共5页
Letters in Biotechnology
关键词
信号分子
细菌耐药机制
氧化应激
signaling molecule
mechanism of bacterial antibiotics resistance
oxidative stress
