摘要
γ-氨基丁酸(GABA)是广泛分布于哺乳动物中枢神经系统的重要抑制性神经递质。GABA及其受体还广泛存在于多种外周组织中,参与细胞间的信息传递及调控内分泌活动。近年来,大量研究证实GABA及其受体也在女性生殖过程和相关生殖疾病中发挥特异性作用。GABA信号调节卵泡发育过程中雌、孕激素的分泌,从而影响卵泡发育和成熟。同时,GABA通过与不同类型的受体结合参与胚胎植入和胎盘发生过程。此外,GABA及其受体还可通过特定的信号转导通路调控多种生殖疾病的发生、发展,并且与某些肿瘤的增殖和转移等恶性潜能有关。重点综述GABA及其受体在女性生殖生理和生殖疾病中的研究进展,并展望其在生殖领域的研究前景。
GABA is a principal inhibitory neurotransmitter in the central nervous system of mammalian.However, GABA and its receptor are present not only in peripheral neuronal tissue, but also in many peripheral non-neuronal tissues, suggesting that GABA plays important roles in regulating signal transduction and endocrine function. Recently, many studies showed that GABA and its receptors also play some special roles in the female reproduction and reproductive disorders. GABA signaling is involved in follicular development and maturation by regulating estrogen and progesterone production. Meanwhile, GABA through various GABA receptors can regulate embryo implantation and placentation. In addition, GABA and its receptors are related to many reproductive diseases by some specific signaling pathways, including tumor proliferation and metastasis. This review discussed the research progress of GABA and its receptors in the female reproductive processing and related diseases.
出处
《国际生殖健康／计划生育杂志》
CAS
2015年第4期312-314,318,共4页
Journal of International Reproductive Health/Family Planning
基金
国家自然科学基金项目(81170622)
关键词
Γ-氨基丁酸
受体
GABA
卵泡
胎盘
肿瘤
Gamma-aminobutyric acid
Receptors
GABA
Ovarian follicle
Placenta
Neoplasms
