摘要
抗菌肽(antimicrobial peptides,AMPs)是自然界生物体内非常重要的防御体系,能够对抗细菌、真菌、病毒甚至肿瘤细胞。抗菌肽具有广谱抗菌活性,且不易产生耐药性,这使得抗菌肽成为应用前景非常广阔的抑菌剂。本文综述了抗菌肽的来源、功能及其作用机制,并对其应用前景进行展望。
Antimicrobial peptides （ AMPs） are critical component of the innate immune system of organisms, and have been demonstrated with the activity against a variety of microorganisms including bacteria, yeast, fungi, viruses and even tumor cells.Broad-spectrum activity and low propensity for resistance development make the AMPs as a kind of great potential for development of new anti-infective agents.In this paper, the origins, the action, the mechanism, the application prospects are reviewed.
出处
《中国生化药物杂志》
CAS
2015年第5期181-185,共5页
Chinese Journal of Biochemical Pharmaceutics
基金
国家自然科学基金面上项目(核磁共振研究抗菌肽与细胞膜相互作用的分子机制
No.21372222)
关键词
抗菌肽
来源
功能
机制
应用前景
antimicrobial peptides
origins
action
mechanism
application prospects
