摘要
目的:观察卡孕栓联合缩宫素用于疤痕子宫二次剖宫产术后的止血效果。方法:88例疤痕子宫二次剖宫产妇随机分为两组,对照组产妇单用缩宫素治疗,联合组产妇采用卡孕栓联合缩宫素治疗。统计两组患者术中、术后出血量,术后血压和术中凝血功能指标,并统计产妇控制出血措施和术后不良反应情况。结果:联合组产妇的产后出血发生率明显低于对照组产妇(P<0.05),术中、术后2 h和术后24 h出血量均明显少于对照组产妇(P<0.05)。两组产妇术后血压比较差异无统计学意义(P>0.05),术中凝血功能指标比较,差异有统计学意义(P<0.05)。联合组产妇术中术后采用子宫按摩、手术和使用药物止血措施的例数均明显少于对照组产妇(P<0.05)。两组产妇不良反应发生率比较,差异无统计学意义(P>0.05)。结论:卡孕栓联合缩宫素可有效减少疤痕子宫二次剖宫产术后出血,效果显著,安全性高。
Objective：To observe the hemostasis effects of carprost combined with oxytocin on scar uterine after second cesarean section. Methods ：88 cases of second cesarean section women with scar uterine were randomly divided into two groups . The control group were treated with only oxytocin while the combination group were treated with carprost combined with oxytoein. Intraoperative and postoperative blood loss, postoperative blood pressure, intraoperative coagulation function index of the two groups were compared, the measures to control bleeding and adverse drug reactions of two groups were observed. Results：The incidence of postpartum hemorrhage in the combination group was significantly lower than the control group （P 〈 0.05 ）, and intraoperative blood loss, 2 hours and 24 hours postoperative blood loss of the combination group were all less than those of the control group （ P 〈 0.05 ）. The postoperative blood pressure of two groups patients were no significant difference （P 〉 0.05 ）. PT and APTT levels of the combination group was significantly lower than the control group while their D-D and FIB levels were significantly higher（ P 〈 0.05 ）. The incidence of adverse drug reactions of two groups had no significant difference （ P 〉 0.05 ）. Conclusion： Carprost combined with oxytocin can effectively reduce bleeding on scar uterine after second cesarean. It was efficacy and safe.
出处
《药物流行病学杂志》
CAS
2015年第7期403-405,共3页
Chinese Journal of Pharmacoepidemiology
基金
2014年苍南县第一批科技计划项目(编号:2014S06)
关键词
剖宫产
卡孕栓
缩宫素
产后出血
Cesarean section
Carprost
Oxytocin
Postpartum hemorrhage
