摘要
目的探讨早期自然流产患者胎盘绒毛滋养细胞中Fas、Survivin、Ki-67的表达及意义。方法采用免疫组化Max Vision法检测Fas、Survivin和Ki-67在48例早期自然流产和25例早期正常妊娠(作为对照组)妇女的胎盘绒毛滋养细胞中的表达。结果自然流产组中Fas强阳性表达高于对照组(P<0.05),而Survivin和Ki-67则明显低于正常组,差异有统计学意义(P<0.01)。结论胎盘绒毛滋养细胞中Fas表达上调或Survivin和Ki-67表达下调可能是引起早期自然流产的重要原因。
Objective：To investigate the expression and the significance of Fas and Survivin and Ki-67 in placenta villi nutrient cells of patients with early spontaneous abortion. Methods：The expression of Fas and Survivin and Ki-67 in placenta villi nutrient cells of 48 patients with early abortion and 25 early normal pregnancy（as the control group）were detected by immunohistochemistry. Results：The expression of Fas strong positive in early spontaneous abortion group was higher than the control group（P〈0.05）,and Survivin and Ki-67 is significantly lower than normal group. The difference was statistically significant（P〈0.01）. Conclusions：The expression of Fas was rised or the expression of Survivin and Ki-67 were reduced in placenta villi nutrient cells may be an important cause of early spontaneous abortion.
出处
《中国优生与遗传杂志》
2015年第7期20-21,56,共3页
Chinese Journal of Birth Health & Heredity
基金
兰州市医疗卫生类科技支撑计划(2013-3-48)
