摘要
目的探讨MTHFR基因C677T、G1793A多态位点与糖尿病心脏病的关系。方法应用PCR对病例组(175例)和对照组(124例)的MTHFR基因C677T、G1793A多态位点进行检测,比较两组间的基因频率和基因型频率。结果 C677T多态位点:病例组CC基因型频率、CT基因型频率、TT基因型频率与对照组相应基因型频率差异无显著性意义(P>0.05);G1793A多态位点:病例组GG基因型频率、GA基因型频率与对照组相应基因型频率差异无显著性意义(P>0.05)。结论 MTHFR基因突变导致血中的同型半胱氨酸水平升高,可能参与了糖尿病心脏病的发生、发展,但并不是一个重要因素。
Objective：To discuss the relationship between C677 T,G1793A polymorphism of MTHFR gene and diabetic cardiopathy. Methods：The PCR method was used to detect the C677 T and G1793 A polymorphism of MTHFR gene,and the frequencies of gene and genotype were subjected to statistical analysis. Results：For the C677 T polymorphism,comparing with control group there was no significant difference in distribution among the genotype frequency of CC,CT and TT. For the G1793 A polymorphism,comparing with the control group there was no significant difference in distribution among the genotype frequency of GG,GA and AA. Conclusion：The high level blood homocysteine which caused by the mutations of MTHFR gene,maybe related to the diabetic cardiopathy,but not an important factor.
出处
《中国优生与遗传杂志》
2015年第7期14-15,共2页
Chinese Journal of Birth Health & Heredity
基金
黑龙江省教育厅科学技术研究(面上)项目(12541903)
