摘要
排斥导向分子(repulsive guidance molecule,RGM)家族包含RGMa、RGMb和RGMc三个成员。RGMb在神经、生殖、免疫系统及肾脏、肺、肌肉等重要器官均有表达,并可通过多种途径调节胚胎发育、免疫系统活性、细胞间黏附、肿瘤发生、损伤修复等重要生理过程。RGMb主要参与RGMb-neogenin-Rho信号通路和BMP信号通路,最近发现的PD-L2-RGMb结合作用提示以RGMb为中心的细胞信号网络与功能调节极为复杂。该文将以RGMb为重点,对与其相关的信号通路、生理功能调节及研究进展加以介绍。
The repulsive guidance molecule （RGM） family includes three members ： RGMa, RGMb and RGMc. RGMb has been found in many tissues and organs, such as the nervous system, the reproductive system, the immune system, kidney, lung and muscle, etc. Accumulated evidences show that RGMb is related to embryonic development,immunoregulation, cell-to- cell adhesion, tumorigenesis, tissue repair, and other physiological processes. RGMb-neogenin- Rho signaling pathway and BMP signaling pathway play key roles in RGMb related functional regulation. This article focused on RGMb and reviewed the current knowledge regarding its structure, expression localization, signaling pathway, and physiological/pathophysiological functions.
出处
《神经药理学报》
2014年第2期46-54,共9页
Acta Neuropharmacologica
基金
国家自然科学基金项目(No.30870921
No.81170632
No.81261160507)
科技部国际科技合作与交流专项项目(No.2012DFA11070)
教育部高等学校博士学科点专项科研基金项目(No.20100001110047)
