摘要
目的 探讨降钙素原（PCT）、高迁移率族蛋白B1（HMGB1）对急性胰腺炎（AP）病情程度及预后的评估价值。方法 分析2013年10月~2014年12月我院收治的160例AP患者临床资料,根据《2013年中国急性胰腺炎诊治指南》,将所有患者分为轻度急性胰腺炎（MAP）组、中度急性胰腺炎（MASP）组和重度急性胰腺炎（SAP）组,分别对比入院后24 h内3组血清PCT、HMGB1水平,并对结果 进行对照分析。另选择同期本院体检的健康人50例为正常对照组。结果 AP患者的PCT、HMGB1水平明显高于正常对照组,且随着AP病情的加重,PCT、HMGB1水平呈进行性升高（P〈0.05）。结论 早期检测PCT和HMGB1,可尽早明确AP患者的病情,有助于指导临床治疗及评估预后。
Objective To discuss the value of procalcitonin （PCT） and high mobility group box protein 1 （HMGB1） in the evaluation of the pathogenetic condition and prognosis of acute pancreatitis （AP）. Methods Analysis was made in the clinical data of 89 patients with AP who were hospitalized between October 2013 and December 2014. Those patients were divided into mild acute pancreatitis （MAP） group, moderate acute pancreatitis （MSAP） group, and severe acute pancreatitis （SAP） group according to the Guidelines for Clinical Diagnosis and Classification of Acute Pancreatitis in China, 2013. Comparison was made respectively among the levels of serum PCT and HMGB1 within 24 hours after the hospitalization in those three groups, and control analysis was made in the results. Moreover, 50 healthy cases were selected as control group. Results The AP patients＂ PCT and HMGB1 levels were significantly higher than those in the normal control group （P 〈 0.05）. And along with the aggravation of AP, the PCT and HMGB1 levels progressively increased （P 〈 0.05）. Conclusion Early detection of PCT and HMGB1 can make the AP patietns＇ pathogenetie condition clear as early as possible and help guiding the clinical treatment and estimating the prognosis.
出处
《西南国防医药》
CAS
2015年第7期714-716,共3页
Medical Journal of National Defending Forces in Southwest China
关键词
急性胰腺炎
早期诊断
预后
降钙素原
高迁移率族蛋白B1
acute pancreatitis
early diagnosis
prognosis
procalcitonin
high mobility group box protein 1
