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血清前降钙素在新生儿重症感染中的诊断价值

Diagnostic Value of Serum Procalcitonin in Neonate with Severe Bacterial Infection
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摘要 目的探讨血清前降钙素(PCT)在新生儿重症感染中的诊断价值。方法应用免疫荧光法对115例重症感染新生儿(细菌感染组75例,病毒感染组40例)和30例无感染征象患儿(对照组)入院时进行血清PCT测定,采用免疫散射比浊法检测CRP和WBC计数,检测结果分为PCT〈0.5μg/L,0.5~2.0μg/L,2.0~10.0μg/L,≥10.0μg/L4个等级,PCT〉0.5μg/L为阳性,〉2.0μg/L为强阳性。对明确细菌感染的新生儿复查PCT及CRP水平。结果细菌感染组PCT阳性率为96%(72/75例),病毒感染组PCT阳性率为35%(14/40例),对照组PCT阳性率为6.67%(2/30例)。3组间PCT阳性率两两比较,差异有显著意义(P〈0.01)。细菌感染组PCT强阳性率为44%(33/75例),与病毒感染组(10%)和对照组(0)比较,差异均有显著意义(Pa〈0.01);病毒感染组PCT强阳性率与对照组比较,差异无显著意义(P〉0.05)。细菌感染组CRP阳性率明显高于病毒感染组和对照组(Pa〈0.05);病毒感染组与对照组CRP比较,差异无显著意义(P〉0.05)。细菌感染组治疗后5例PCT≥10.0μg/L,2例死亡,3例病情恶化自动出院。结论血清PCT是鉴别细菌感染和病毒感染、细菌感染预后判断及治疗监测的主要指标之一。
出处 《实用儿科临床杂志》 CAS CSCD 北大核心 2008年第14期1086-1087,共2页 Journal of Applied Clinical Pediatrics
基金 佛山市医学科学发展基金项目资助(200508085)
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