摘要
目的探讨肿瘤体外药敏试验对复发性卵巢癌患者治疗的意义。方法收集复发性卵巢癌患者新鲜组织样本并进行瘤体外药敏试验。试验采用双盲法,由肿瘤科医生根据患者情况,从15种治疗方案中选择一种对患者进行治疗。根据治疗效果将患者分为3组:敏感组(S组);中度敏感组(I组);不敏感组(R组)。对患者的无病进展期(PFS)和总生存期(OS)进行检测。分析临床医生根据治疗反应选择的治疗方案同PFS和OS的关系。结果共入组262名患者,实验证明敏感组患者(S组),经过化疗后PFS和OS得到显著改善,而I组和R组的临床结局无显著差异。I+R组患者(HR=0.66,P=0.008)的中位PFS为8.9个月,OS为5.8个月。化疗反应检测的结果与患者治疗时顺铂敏感性结果相一致(HR:0.72 vs.0.66),多因素回归分析表明:顺铂敏感性是预后的独立因素(HR=0.66,P=0.021)。平均OS延长14个月(S组为37.6个月vs.I+R组23.8个月,HR=0.62,P=0.011)。结论肿瘤体外药敏检测结果指导临床化疗与患者的临床疗效有很好的相关性,对指导复发性卵巢上皮癌患者个体化化疗有重要临床价值。
Objective To evaluate the clinical value of tumor chemosensitivity test in the guidance of the advanced epithelial ovarian carcinoma patients treated with chemotherapy.Methods Women with ovarian cancer were enrolled and fresh tissue samples were collected for chemoresponse testing.Oncologists chose a drug for each patient according to the patient’ s condition by double blind method.Each treatment was classified by the assay as： sensitivity （S）; moderate sensitivity （I）;resistant （R）.Progression-free survival （PFS） and overall survival （OS） were detection.The relationship between treatment response and PFS or OS was analysis.Results 262 patients were enrolled.The PFS and OS were significantly improved in sensitivity patients （S） after chemotherapy,but no significant difference were found in I and R groups.In I＋R groups （HR=0.66,P=0.008） , median PFS was 8.9 months, OS was 5.8 months.Chemotherapy response test results was consistent with clinical results cisplatin sensitive and resistant （ HR：0.72 vs.0.66）.Multi factor regression analysis showed that tumor chemosensitivity test was independent prognostic factors （HR =0.66, P =0.021）.The average OS extended for 14 months （37.6 months for the S group vs.group I ＋R 23.8 months,HR =0.62, P =0.011）.Conclusion Tumor chemosensitivity assay is correlated with the clinical effects and might play an important role in guiding the recurrent epithelial ovarian cancer patients with individualized chemotherapy.
出处
《中国生化药物杂志》
CAS
2015年第4期84-87,共4页
Chinese Journal of Biochemical Pharmaceutics
关键词
化疗反应实验
卵巢癌
药物敏感性
chemotherapy reaction experiment
ovarian tumor
chemosensitivity
