摘要
目的探讨稳定期慢性阻塞性肺疾病(COPD)患者认知功能的影响因素。方法选取2013年1月-2014年11月期间该院收治的128例稳定期COPD患者为病例组,并选择同期来该院体检的75名健康成人为对照组。比较两组及病例组中各亚组的蒙特利尔认知评估量表(Mo CA)评分,通过简单线性相关和多重线性回归分析患者的Mo CA评分与各因素的关系。结果病例组的Mo CA评分显著低于对照组(P<0.05)。年龄、吸烟指数、受教育时间、COPD严重程度、病程、Pa O2、Pa CO2、SO2、SAS及SDS评分的各亚组的Mo CA评分比较,差异有统计学意义(P<0.05)。Mo CA评分与Pa O2、SO2成正相关,与年龄、COPD严重程度、SDS评分负相关(P<0.05)。结论稳定期COPD患者存在不同程度的认知功能障碍,高龄、肺功能显著降低、低氧血症、抑郁表现是患者发生认知功能障碍的高危因素,应进行早期诊治。
[ Objective ] To investigate the relevant factors of cognitive function in patients with stable chronic ob- structive pulmonary disease （COPD）. [Methods] Totally 128 patients with stable COPD from January 2013 to November 2014 were enrolled into the case group and 75 healthy adults who received health examination in our hospital over the same period were selected as the control group. Montreal Cognitive Assessment Scale （MoCA） score was compared between the two groups and among all the subgroups of the case group. Simple linear correlation and multiple linear regression analysis were performed to analyze the relationship between MoCA score and each factor. [Results] MoCA score of the case group was significantly lower than that in the control group （P 〈 0.05）. There were significant differences in age, smoking index, education time, severity of COPD, course of disease, PaO2, PaCO2, SO2, SAS and SDS score among the subgroups （P 〈 0.05）. MoCA score was positively correlated with PaOa and S02, and negatively correlated with age, severity of COPD and SDS score （P 〈 0.05）. [ Conclusions ] Patients with stable COPD have different degree of cognitive dysfunction. Elderly, significantly decreased pulmonary function, hypoxemia and depression are the risk factors for patients with cognitive dysfunction who should be early diagnosed and treated.
出处
《中国现代医学杂志》
CAS
北大核心
2015年第15期75-79,共5页
China Journal of Modern Medicine
关键词
慢性阻塞性肺疾病
认知功能
蒙特利尔认知评估
chronic obstructive pulmonary disease
cognitive function
Montreal cognitive assessment
