摘要
目的:探讨血清脂联素、瘦素与2型糖尿病(T2DM)患者轻度认知功能障碍(MCI)的关系。方法:对60例T2DM患者应用蒙特利尔认知评估(Mo CA)量表测评认知功能,然后分为T2DM-MCI组(25例)和T2DM认知功能正常(T2DM-NC)组(35例),另选择糖耐量正常且认知功能正常者25例作为对照组(NGT-NC组)。对入选病例测定血清脂联素、瘦素,并测定糖化血红蛋白(Hb A1c)、血脂。结果:T2DM-MCI组脂联素水平为(3.31±0.22)mg/L,低于T2DM-NC组的(5.39±0.38)mg/L及NGT-NC组的(11.53±0.29)mg/L(F=175.921,P<0.001);T2DMMCI组瘦素水平为(16.24±0.18)μg/L,高于T2DM-NC组的(13.43±0.25)μg/L及NGT-NC组的(5.41±0.19)μg/L(F=475.478,P<0.001)。T2DM-MCI组Mo CA评分与Hb A1c(r=-0.596,P=0.002)、糖尿病病程(r=-0.533,P=0.006)、瘦素(r=-0.674,P<0.001)呈负相关,与脂联素(r=0.693,P<0.001)呈正相关。多重线性回归分析结果显示:脂联素(标准化β=0.481,P=0.002)、瘦素(标准化β=-0.370,P=0.010)、Hb A1c(标准化β=-0.305,P=0.012)是Mo CA评分的危险因素。结论:血清脂联素、瘦素、Hb A1c是T2DM患者MCI的危险因素;病程不同程度参与了T2DM患者MCI的形成。
Aim：To explore the relationship between mild cognitive impairment （ MCI） and adiponectin and leptin in type 2 diabetes mellitus（T2DM） patients.Methods：A total of 60 T2DM patients were divided, based on cognitive function assessed by Montreal cognitive assessment （MoCA） scale, into two groups, namely 25 T2DM patients with MCI （T2DM-MCI group） and 35 T2DM patients with normal cognitive function （T2DM-NC group）.Another 25 subjects with normal glu-cose tolerance and normal cognitive function were chosen as normal control （ NGT-NC） .Serum adiponectin and leptin were measured.HbA1c and lipid levels were also determined .Results： In comparison with T2DM-NC group [（5.39 ±0.38） mg/L] and NGT-NC group [（11.53 ±0.29） mg/L], adiponectin was significantly lower in T2DM-MCI group [（3.31 ± 0.22） mg/L] （F=175.921, P〈0.001）;while in comparison with T2DM-NC group [（13.43 ±0.25）μg/L] and NGT-NC group[（5.41 ±0.19） μg/L], leptin was significantly higher in T2DM-MCI group[（16.24 ±0.18） μg/L] （F=475.478, P〈0.001）.In T2DM-MCI group, MoCA score was negatively correlated with HbA 1c （r=-0.596, P=0.002）, diabetic duration （r=-0.533, P=0.006） and leptin （r=-0.674, P〈0.001）, but was positively correlated with adiponectin （r=0.693, P〈0.001）.Multiple linear regression analysis suggested that adiponectin , leptin and HbA1c were the risk fac-tors of MoCA score（standadized β=0.481,-0.370, and -0.305,P〈0.05）.Conclusion：Adiponectin, leptin and HbA1c are the risk factors for diabetic cognitive impairment .Diabetic duration contributes in a sense to the forming of MCI .
出处
《郑州大学学报（医学版）》
CAS
北大核心
2015年第2期210-213,共4页
Journal of Zhengzhou University(Medical Sciences)
基金
国家自然科学基金项目61151003
河南省科技攻关计划项目122102310136
关键词
2型糖尿病
轻度认知功能障碍
蒙特利尔认知评估
脂联素
瘦素
type 2 diabetes mellitus
mild cognitive impairment
Montreal cognitive assessment
adiponectin
leptin
