摘要
目的:探讨非综合征性唇腭裂发病的孕前及孕期环境危险因素,为减少非综合征性唇腭裂的发生提供参考依据。方法:选择100例临床确诊为唇腭裂患者的母亲为病例组,100例同期出生未患唇腭裂婴儿的母亲为对照组,进行问卷调查,调查内容有孕妇基本情况(年龄、民族、职业、文化程度、孕次等),对调查结果进行χ2检验单因素分析,Logistic回归作多因素分析。结果:单因素分析发现影响唇腭裂发生的孕前和孕早期环境危险因素有:接触有害物质、孕前或孕早期患病、不良生活习惯、营养不良、服用药物和母亲文化成功低,Logistic回归分析发现有害物质接触、孕前或孕早期患病、不良生活习惯、营养不良、服用药物5个因素影响唇腭裂发生。结论:有害物质接触、孕前或孕早期患病、不良生活习惯、营养不良、服用药物可能是贵州省发生先天性唇腭裂的主要环境危险因素。
Objective： To investigate the risk factors before pregnancy and during pregnancy environmental incidence of nonsyndromic cheilopalatognathus（ NSCL / P）,to provide reference for reducing the incidence of NSCL / P. Methods： A total of 100 mothers of patients diagnosed NSCL / P as case group,and another 100 mothers of healthy children as control group. Both groups were conducted questionnaire survey,and results were sent for χ^2 test for the univariate analysis,and multiple factor analysis was analyzed by Logistic regression test. Results： Univariate test found that environmental risk factors influencing the occurrence of NSCL / P before pregnancy and early pregnancy included： exposure to harmful substances,pregnancy or early pregnancy illness,bad habits,poor nutrition,medication and under educated mother. Logistic regression model discovered exposure to harmful substances,pregnancy or early pregnancy illness,bad habits,poor nutrition,medication triggered incidence of the cleft lip and palate. Conclusions： Harmful contact substances,preconception or early pregnancy illness,bad habits,poor nutrition,medication may be the main environmental risk factors influencing the occurrence of congenital cleft lip and palate in Guiyang.
出处
《贵阳医学院学报》
CAS
2015年第5期511-513,共3页
Journal of Guiyang Medical College
关键词
口颌系统畸形
唇腭裂
问卷
危险因素
stomatognathic system abnormalities
cleft lip and palate
questionnaires
risk factors
