摘要
目的 探讨奥扎格雷钠联合盐酸小檗碱治疗急性脑梗死疗效及其对糖脂代谢的影响.方法 将158例脑梗死急性期患者按数字表法随机分为使用奥扎格雷钠对照组和联合应用奥扎格雷钠与盐酸小檗碱观察组,在治疗前和治疗2周后按照中国脑卒中临床神经功能缺失评分量表及美国国立卫生研究院卒中量表（NIHSS）测试其神经功能缺失情况,评价临床神经功能情况;治疗后1、3、6个月测其日常生活活动能力量表,评价联合用药远期恢复情况.采用浊度法测定各组糖脂指标水平的变化.结果 治疗2周后观察组总有效率为87.01％,明显高于对照组的69.14％（χ2=7.316,P＜0.01）.观察组患者中国脑卒中临床神经功能缺失评分量表和NIHSS评分均明显优于对照组（=3.207、1.274,均P＜0.叭）.两组治疗后1个月、3个月和6个月后患者日常生活能力与治疗前比较均明显改善（t =7.266和t=8.850、t=1.429和扛2.816、=9.218和t =6.739,均P＜0.01）,治疗3个月和6个月观察组患者日常生活能力优于对照组（t=1.163、t=0.932,均P＜0.01）,两组治疗后6个月与治疗后3个月比较日常生活能力差异均无统计学意义（t=7.861、t =5.005,均P＞0.05）.治疗后观察组空腹血糖值显著下降（t=0.859,P＜0.01）,血清总胆固醇、甘油三酯及低密度脂蛋白水平均显著下降（t =0.257、=0.114和t=0.378,均P＜0.01）,高密度脂蛋白水平虽略有升高,但差异无统计学意义（t=1.960,P＞0.05）.结论 奥扎格雷钠联合盐酸小檗碱治疗急性脑梗死疗效显著,可明显降低患者糖脂代谢水平.
Objective To investigate the effects of sodium ozagrel and berberine hydrochloride in the treatment of acute cerebral infarction and its effect on glucose and lipid metabolism.Methods According to the digital table,158 patients with acute cerebral infarction were randomly divided into the two groups：the control group was treated with the sodium ozagrel group and the observation group was treated combined with sodium ozagrel and berberine hydrochloride.After 2 weeks,Chinese stroke clinical neural function defect score scale and the National Institutes of Health Stroke Scale （NIHSS） was used to evaluate neurological function.The therapeutic effectiveness was assessed by ADL after treatment 1,3,6 months.The changes of glucose and lipid levels were detected by turbidimetric method.Results The total effective ratein the observation group was obviously higher than that of the control group （87.01% vs 69.14%） （χ2 =7.316,P 〈0.01）.Of the above two ways of nerve function score indicateed that the observation group was significantly better than that of the control group （t =3.207,1.274,all P 〈 0.01）.ADL score of all patients was significantly better than that of before treatment with drug in the two groups after 1 month,3 months and 6 months （t =7.266 and t =8.850,t =1.429 and t =2.816,t =9.218 and t =6.739,P 〈0.01）.Compared with the control group,ADL score of the observation group was significantly improved after 3 months and 6 months （t =1.163,0.932,all P 〈0.01）.The significant difference was found between the control group and the observation group after 3 months and 6 months （t =7.861,5.005,all P 〉 0.05）.After the treatment,the fasting blood glucose level was reduced significantly in the observation group （t =0.859,P 〈 0.01）,total cholesteroland high-density lipoprotein,triglyceride,low density lipoprotein level were significantly decreased （t =0.257,0.114,0.378,all P 〈 0.01）,but there was no significant difference in HDL-C level （t =1.960,P 〉 0.05）.Conclusion T
出处
《中国基层医药》
CAS
2015年第9期1390-1393,共4页
Chinese Journal of Primary Medicine and Pharmacy
关键词
脑梗塞
小檗碱
奥扎格雷
Brain Infarction
Berberine
Sodium Ozagrel
