摘要
目的观察依达拉奉联合奥扎格雷钠治疗急性脑梗死(ACI)的疗效。方法将140例ACI患者随机分为治疗组和对照组。两组患者均给予调整血压、血糖、血脂、减轻脑水肿、防止并发症、阿司匹林等常规治疗。在此基础上,治疗组加用奥扎格雷钠80 mg,静脉滴注,1次/d,依达拉奉30 mg,静脉滴注,2次/d,14 d为一疗程;对照组加用复方丹参20 ml,胞二磷胆碱0.75 g,分别静脉滴注,均1次/d,14 d为一疗程。观察两组治疗后临床神经功能缺损程度评分、日常生活能力(ADL)评分及临床疗效。结果治疗组总有效率91.4%(64/70),对照组总有效率80.0%(56/70),两组对比差异有统计学意义(P<0.05)。治疗组与对照组相比,治疗后临床神经功能缺损程度评分明显下降,ADL评分明显上升,差异均有统计学意义(P<0.01)。治疗组出现2例肝功能损害,停药后自行恢复正常。结论依达拉奉联合奥扎格雷钠治疗ACI能有效改善神经功能、临床症状及生活质量,疗效十分显著、安全性较高,不良反应少而轻,值得推广应用。
Objective To observe the efficacy of ozagrel combined with edaravone in treatment of acute cerebral infarction（ACI）.Methods One hundred and forty cases of ACI were randomly divided into treatment group and control group.Patients in both groups were treated with adjusting blood pressure,blood glucose,blood lipids and cerebral edema,preventing complications,taking aspirin and other conventional treatment.On this basis,treatment group were treated with ozagrel 80 mg,intravenous infusion,1 time/day,edaravone 30 mg,intravenous infusion,2 times/day,14 days for a course of treatment;The control group were treated with compound salvia 20 ml,citicoline 0.75 g,respectively,intravenously,both were 1 time/day,14 days for a course of treatment.The clinical neurological deficit scores,activities of daily living（ADL）,and clinical efficacy after treatment were observed.Results The total effective rate in treatment group was 91.4%（64/70）,the control group was 80.0%（56/70）,of which the difference was statistically significant（P0.05）.Treatment group compared with the control group after treatment,clinical neurological impairment score was significantly decreased,ADL scores was significantly increased,the differences were statistically significant（P0.01）.Two cases occured liver injury in treatment group,which returned to normal after treatment.Conclusion Ozagrel combined with edaravone in treatment of ACI can effectively improve neurological function,clinical symptoms and quality of life,has very significant effects,safety,and adverse reactions are few and mild,should be widely applied.
出处
《临床医学》
CAS
2011年第11期15-17,共3页
Clinical Medicine
