摘要
目的研究同型半胱氨酸、叶酸、维生素B12水平与急性脑梗死的关系。方法参照Pullicinp法将2011年8月至2013年12月期间接受治疗的急性脑梗死轻度、中度和重度患者各50例纳入研究的观察组,同期体检健康者50例纳入研究的对照组。检测血清中同型半胱氨酸、叶酸、维生素B12水平,并采用美国国立卫生研究院卒中量表(NIHSS量表)、简易精神状态评价量表(MMSE量表)和日常生活活动能力(ADL)量表评价神经功能、认知功能以及生活能力。结果脑梗死患者的同型半胱氨酸水平高于对照组,叶酸、维生素B12水平低于对照组,轻度、中度和重度间比较差异有统计学意义;梗死组患者NIHSS评分、MMSE评分、Barthel指数明显低于对照组,轻度、中度和重度梗死间比较差异有统计学意义,梗死面积越大,NHISS评分、MMSE评分、Barthel指数越低;血清同型半胱氨酸水平与NIHSS评分呈正相关,与MMSE评分、Barthel指数呈负相关;叶酸、维生素B12含量与NIHSS评分呈负相关,与MMSE评分、Barthel指数呈正相关。结论急性脑梗死患者血清中同型半胱氨酸、叶酸、维生素B12水平发生改变,且与治疗后的神经功能、认知功能以及生活能力存在良好的相关性,是判断预后情况的理想指标。
Objective To study the relationship between homocysteine,folate,vitamin B12 levels and acute cerebral infarction. Meth-ods 50 cases of mild infarction,moderate infarction and severe infarction in our hospital from 2011 August to 2013 December were enrolled in ob-servation group and 50 cases of healthy persons underwent physical examination in our hospital were enrolled in control group. Then serum homo-cysteine,folate,vitamin B12 content were detected,nerve function,cognitive function and life ability were evaluated by NIHSS scale,MMSE scale and ADL scale. Results Patients with cerebral infarction Homocysteine levels was significantly higher than that of the control group,folic acid,vitamin B12 levels was lower than control group. There were statistically significant between mild,moderate and severe. The patients with cerebral infarction NIHSS,MMSE,Barthel was significantly lower than control group,there were statistically significant between mild,moderate and severe. The serum Hcy levels were positively correlated with NIHSS score and negatively correlated with MMSE score,Barthel index. The fo-late,vitamin B12 levels were negatively correlated with NIHSS score and positively correlated with MMSE score,Barthel index. Conclusion Ser-um homocysteine,folate,vitamin B12 content change in patients with acute cerebral infarction and are ideal index to evaluate prognosis for their levels,which have good correlation with nerve function,cognitive function and life ability.
出处
《临床和实验医学杂志》
2015年第9期715-718,共4页
Journal of Clinical and Experimental Medicine
基金
2014佛山市医学类科技攻关项目(编号2014AB00352)
项目名称:叶酸治疗合并HHcy的腔隙性脑梗死的远期观察
