摘要
目的:探讨血清同型半胱氨酸(Hcy)与癫痫患者认知功能损害(MCI)的相关性。方法:将120例癫痫患者按照认知功能是否存在损害分为MCI组(51例)和非MCI组(69例),对两组患者Hcy、S-腺苷甲硫氨酸(SAM)、S-腺苷同型半胱氨酸(SAH)水平进行测定,并探讨Hcy水平与简易精神状态评价量表(MMSE)评分的相关性。结果:MCI组患者血清Hcy、SAH水平均明显高于非MCI组(P<0.05),MCI组患者血清SAM水平明显低于非MCI组(P<0.05),当血清Hcy水平<15.0μmo L/L时,患者MMSE评分与血清Hcy浓度无明显相关性(r=-0.19,P>0.05);当血清Hcy水平≥15.0μmo L/L时,患者MMSE评分与血清Hcy浓度呈负相关性(P<0.05)。结论:血清Hcy与癫痫患者MCI有一定相关性,临床可据此进行辅助诊断。
Objective： To study the relationship between serum homocysteine （Hcy） and cognitive impairment （MCI） in patients with epilepsy. Methods： 120 patients with epilepsy were divided into MCI group （ n = 51 ） and non MCI group according to the impairment of cognitive function （ n = 69 ）. The Hcy, S-adenosine methionine （SAM ） , S-adenosine homocysteine （SAH） levels of were determined, and the Hcy levels and simple mental state assessment scale （ MMSE ） score were detected. Results： The serum level of Hcy and SAH of patients in MCI group were significantly higher than that in MCI group （ P 〈 0.05 ） ; SAM serum level in patients with MCI group was obviously lower than the MCI group （ P 〈 0.05 ） ; while serum Hcy levels 〈 15. 0 umoL/L, MMSE score and serum Hey concentration in patients had no significant correlation （r = 0.19, P 〉 0.19） ; When serum Hcy levels acuity 15.0 mu moL/L, MMSE score and serum Hcy concentration had negative correlation （P 〈 0.05）. Conclusion： There are some correlations between serum Hey and epilepsy patients with MCI. Clinical diagnosis can be carried out accordingly it.
出处
《河北医学》
CAS
2017年第1期35-37,共3页
Hebei Medicine
基金
辽宁省科技厅计划项目
(编号:2004225003-8)
