长春西汀注射液治疗急性脑梗死的疗效观察被引量：4

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摘要目的探讨长春西汀注射液治疗急性脑梗死的临床疗效及治疗机制。方法将116例急性脑梗死患者分为对照组和治疗组各58例,在常规治疗基础上,治疗组给予长春西汀注射液20mg,同时给予奥扎格雷钠80mg静脉滴注14d;对照组仅给予奥扎格雷钠80mg静脉滴注14d,观察2组治疗前后的临床疗效、神经功能缺损程度评分及血清炎性因子高敏C-反应蛋白(Hs-CRP)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)和肿瘤坏死因子α(TNF-α)含量的变化。结果治疗组总有效率89.66%高于对照组的81.3%(P<0.05);治疗组治疗后神经功能缺损程度评分显著降低(P<0.01),血清内Hs-CRP、IL-6、IL-8和TNF-α水平显著降低,差异均有统计学意义(P<0.05)。结论长春西汀注射液通过抗炎性反应机制治疗急性脑梗死。

作者张建荣李玉芳王平华李丽华

机构地区河北省正定县人民医院

出处《临床合理用药杂志》 2015年第14期46-47,共2页 Chinese Journal of Clinical Rational Drug Use

关键词长春西汀急性脑梗死炎性因子

分类号 R743.3 [医药卫生—神经病学与精神病学]

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