摘要
目的:研究祛风湿中药对环磷酰胺(CTX)所致免疫功能低下模型小鼠免疫功能的影响。方法:采用环磷酰胺建立小鼠免疫低下模型,测定灌胃给药后小鼠体内碳粒廓清水平和血清溶血素抗体水平。结果:四大类中药均有不同程度的提高免疫抑制小鼠碳粒廓清率,促进血清溶血素形成,在2个免疫增强作用的试验中,辛温(热)合归脾胃经药均表现出很强的免疫增强作用,其次是祛风湿强筋骨药也具有较强的免疫增强作用,另外2大类祛风湿止痹痛药和舒筋活络药有一定作用。结论:免疫作用可能是祛风湿中药的共同药理作用之一,辛温(热)合归脾胃经药表现出较强的免疫增强作用为临床应用提供了理论支持,同时完全支持提出将其归为第四类祛风湿中药的观点。
Objective ： study the effect of anti - rheumatics on immunity of immune -~ deficient mice induced by cyclo- phosphamide. Method： Immune - deficient mice model was established by cyclophosphamide. The carbon particle clear- ance level and Levels of serum hemolysin antibody in mice body were mesured after gastric perfusion. Results ： Every of four kinds of herbs has different effect of increasing carbon particle clearance rate and Promoting serum hemolysin forma- tion in immune inhibited mice. In two experiments of immune enhancement, all herbs of pungent and warming interior stomach meridian medicine have strong effect of enhancing immunity and those of anti - rheumatism and strengthening bones and muscules come the second. Other two kinds of anti - rheumatism and abirritation medicine and ease - tendon and meridian medicine have certain effect. Conclusion： Immunity may be the common pharmacological effect of anti - rheu- matics. The strong effect of pungent and warming interior stomach meridian medicine for enhancing immunity theoretically supports clinical application, and meanwhile, supports our opinion to classify them into the fourth kind of anti - rheumatic herbs.
出处
《中华中医药学刊》
CAS
北大核心
2015年第5期1171-1175,共5页
Chinese Archives of Traditional Chinese Medicine
基金
陕西省科学技术厅自然基金项目(2012JM4001)
关键词
祛风湿中药
碳粒廓清
巨噬细胞
鸡红细胞
溶血素
anti - rheumatic
carbon particle clearance
macrophage
chicken red blood cell
hemolysin
