摘要
采用比色法对给予一定时间、不同剂量绞股蓝总皂甙（ＧＰ）各组小鼠脾自然杀伤细胞活性（ＮＫＣＡ）进行测定。结果显示给予绞股蓝总皂甙剂量为５０ｍｇ／ｋｇ时其自然杀伤细胞活性与对照组比较相同；当剂量为１００ｍｇ／ｋｇ时，小鼠脾自然杀伤细胞活性高于对照组与５０ｍｇ／ｋｇ组；剂量２００ｍｇ／ｋｇ时的自然杀伤细胞活性与１００ｍｇ／ｋｇ相同。提示绞股蓝总皂甙达一定剂量时具有提高小鼠脾自然杀伤细胞活性的作用，当再增加给药剂量时，其进一步促自然杀伤细胞活性作用不明显。
This study examined the effect of gypenosides(GP,0.50,100 and 200 mg/kg)on murine natural killer cells activity(NKCA)of spleens in mice during a 28 day.The results showed that,these were no significant(P>0.05)differrnce between GP(50mg/kg)group and control group.The NKCA of spleen in GP(l00mg/kg)group was significant higher(P<0.0l)than that in control and GP(50mg/kg)groups.However,in the GP (200mg/kg)group splenic NKCA was similar to that in GP(100mg/kg)group/The results suggest that GP could enhance splenic NKCA of mice.
关键词
绞股蓝
皂甙
细胞免疫
杀伤细胞
gypenosides
cellular immunity
natural killer cell
