摘要
目的：研究同型半胱氨酸（Hcy）和C反应蛋白（CRP）在急性脑血管病（CVD）脑出血（ICH）和脑梗死（CI）中的临床应用价值。方法选取ICH患者68例，CI患者69例，以健康体检者117名作为正常对照组。采用循环酶法检测 Hcy，免疫增强比浊法测定CRP，对各组 Hcy、CRP 水平进行比较，并绘制受试者工作特征（ROC）曲线，研究Hcy、CRP与急性CVD的关系及临床应用价值。结果各组血清Hcy含量比较，CI组[15．1（13．1-19．0）μmol／L]和ICH组[13．3（11．2-16．3）μmol／L]均较正常对照组[11．0（9．1-12．9）μmol／L]明显增高（P＜0．01）；各组血清CRP含量比较，CI组[10．5（4．5-41．4）mg／L]和ICH组[30．2（12．3-72．2）mg／L]较正常对照组[0．1（0．1-0．1）mg／L]明显增高（P＜0．01）；各组血清Hcy和CRP异常检出率比较，CI和ICH组与正常对照组差异具有统计学意义（P＜0．01），且CI和ICH组血清Hcy异常检出率差异亦有统计学意义（P＜0．05）；在急性CVD中ROC曲线分析Hcy和CRP，ROC曲线下面积分别为0．762和0．967，诊断急性CVD有显著意义（P＝0．000），Hcy、CRP的含量越高诊断急性CVD的可能性越大。结论血Hcy和CRP水平在CVD患者较健康人群明显升高，且Hcy与CVD存在独立相关性；CRP是评价机体损伤的总体量化指标，在急性CVD的辅助诊断中具有一定的应用价值。
Objective To study the application significance of homocysteine （Hcy） and C reactive protein（CRP） in acute cerebral vascular diseases （ CVD） , like intracerebral hemorrhage （ ICH） and cerebral infarction （ CI） .Methods There were ICH group （68 cases） and CI group （69 cases）.A total of 117 healthy subjects were enrolled as healthy control group.Hcy was determined by cycle enzyme , CRP levels were measured by immuno-enhanced turbidimetry , and the means of Hcy and CRP were compared .The receiver operating characteristic （ ROC ） curve was drawn , and the relation between CRP and acute CVD and the clinical application significance were analyzed .Results The levels of Hcy in CI group [15.1（13.1-19.0）μmol/L] and ICH group [13.3（11.2-16.3）μmol/L] were higher than that in healthy control group [11.0（9.1-12.9）μmol/L, P〈0.01].The levels of CRP in CI group [10.5（4.5-41.4）mg/L] and ICH group [30.2（12.3-72.2） mg/L] were higher than that in healthy control group [0.1（0.1-0.1） mg/L, P〈0.01].Hcy and CRP abnormal rates in CI and ICH groups had significant difference compared with healthy control group （P〈0.01）, and Hcy abnormal rates between CI and ICH groups had difference （P〈0.05）.For acute CVD, the areas under ROC curve of Hcy and CRP were 0.762 and 0.967, and there was significance in the diagnosis of acute CVD （P=0.000）.It could improve the possibility in the diagnosis of acute CVD .Conclusions Serum Hcy and CRP levels increase significantly in patients with CVD compared with healthy subjects , and Hcy and CVD exist independent correlation.CRP as an overall quantitative index to evaluate body injury has a certain significance in the diagnosis of acute CVD.
出处
《检验医学》
CAS
2015年第4期337-340,共4页
Laboratory Medicine
基金
中山市科技计划资助项目(2013A063)
关键词
同型半胱氨酸
C反应蛋白
急性脑血管病
脑梗死
脑出血
受试者工作特征曲线
Homocysteine
C reactive protein
Acute cerebral vascular disease
Cerebral infarction
Intracerebral hemorrhage
Receiver operating characteristic curve
