摘要
目的评价颈动脉内中膜厚度(IMT)联合同型半胱氨酸(HCY)、糖化血红蛋白(HbA1c)及血脂指标检测在脑梗死中的意义。方法选取100例脑梗死患者纳入试验组,并按照病史及血糖检测结果分为糖尿病组、高血糖组及正常血糖组;另选取同期体检健康者60例纳入对照组,检测所有受试者颈动脉IMT及外周血HCY、HbA1c水平。结果试验组IMT增厚的检出率(70%)高于对照组(10%),且试验组的IMT及HCY与HbA1c水平均高于对照组,差异均有统计学意义(P<0.05);糖尿病组与高血糖组的HbA1c水平与IMT均高于正常血糖组,差异均有统计学意义(P<0.05)。IMT联合HCY、HbA1c及血脂指标检测的灵敏度、特异度及准确度分别为97.1%、87.5%、94.0%。结论颈动脉超声联合脑梗死相关生化指标检测可以提高脑梗死的检出率,增加检测的灵敏度、特异度及准确度。
Objective To assess the significance of intima‐media thickness（IM T ）combined with HCY ,HbA1c and blood lipid in‐dexes in patients with cerebral infarction .Methods 100 cases of patients with cerebral infarction were enrolled in the experiment group ,and were divided into normal blood glucose group ,high blood glucose group and diabetes mellitus（DM）group .60 healthy in‐dividuals were enrolled in the control group .The serum leves of HCY and HbA1c were detected ,and the IMT was determined by u‐sing ultrasonic examination .Results The positive rate of increase of IMT in the exprement group（70% ） were higher than that in the control group（10% ） ,there were significant differences between the two groups （P〈0 .05） .The levels of HCY and HbA1c and IMT were higer in the exprement group compared withthose in the control group ,there was significant difference between the two groups（P〈0 .05） .The serum levels of HbA1c and IMT were higher in the high blood glucose group and the DM group compared with those in the control group ,there were significant differences between the two groups （P〈0 .05） .The sensitivity ,susceptibility and accuracy of IMT combined with HCY ,HbA1c and blood lipid indexes were 97 .1% ,87 .5% and 94 .0% .Conclusion The ultrasonic examination combined with biochemical indexes related to cerebral infarction could increase detection rate of cerebral infarc‐tion ,and the ensitivity ,susceptibility and accuracy could also increase .
出处
《国际检验医学杂志》
CAS
2015年第8期1100-1101,1103,共3页
International Journal of Laboratory Medicine
关键词
颈动脉超声
脑梗死
同型半胱氨酸
糖化血红蛋白
颈动脉内中膜厚度
carotid ultrasonic
cerebral infarction
homocysteine
glycosylated hemoglobin
carotid intima-media thickness
