摘要
目的:观察逐瘀逍遥汤联合百会穴针刺对气滞血瘀型脑梗死后抑郁症患者炎性因子的影响及临床疗效。方法:选取我院心脑病科2015年10月~2017年10月收治的100例气滞血瘀型脑梗死后抑郁症患者作为研究对象,采取随机数字表法将患者分为治疗组(50例)与对照组(50例),对照组患者脑梗死常规治疗基础上联合舍曲林治疗,治疗组患者脑梗死常规治疗基础上联合中药逐瘀逍遥汤及针刺百会穴治疗,对比两组患者治疗前、治疗4周、8周后患者抑郁自评量表(SDS)、汉密尔顿抑郁量表(HMAD)评分及炎性因子变化情况、治疗后临床疗效、满意率。结果:治疗前两组患者SDS及HMAD评分相当,P>0. 05,治疗4周、8周后两组患者评分不断改善,且治疗组患者评分优于对照组,P<0. 01,差异具有统计学意义;治疗前两组患者C-反应蛋白(hs-CRP)、肿瘤坏死因子(TNF-α)、白细胞介素6、8 (IL-6、IL-8)炎性因子水平相当,P>0. 05,治疗后4周、8周各组炎性因子水平均显著下降,治疗组显著低于对照组,P<0. 05,差异具有统计学意义;治疗组总有效率为98. 00%,治疗满意率高达98. 00%,均高于对照组86. 00%、82. 00%,P<0. 05,差异具有统计学意义。结论:逐瘀逍遥汤联合百会穴针刺可显著降低气滞血瘀型脑梗死后抑郁症患者炎性因子,临床疗效佳,患者抑郁症状改善,患者高度满意,具有极高临床应用及推广价值。
Objective： To explore the effect of Zhuyu Xiaoyao Decoction combined with acupuncturing at Baihu on inflammatory cytokines for patients with depression after cerebral infarction with Qi-stagnation and blood-stasis type. Methods： Selecting heart attack branch from October 2015 to October 2017,100 patients with depression after cerebral infarction Qi stagnancy and blood stasis syndrome as the research object,took a random number table method divided the patients into treatment group（ 50 cases） and controlled group（ 50 cases） and the controlled group of patients with cerebral infarction based on conventional treatment combined sertraline treatment,the treatment group of patients with cerebral infarction based on conventional treatment was given traditional Chinese medicine（ TCM） Zhuyu Xiaoyao Decoction combined with acupuncturing at Baihu,compared the two groups of patients before and 4 weeks,8 weeks after treatment in patients with depression self rating scale（ SDS） and Hamilton depression scale（ HMAD） score and inflammatory factor,clinical curative effect after treatment,the changes of satisfaction. Results： The two groups of patients before treatment and HMAD score of SDS,P〈0. 05,4 weeks,8 weeks after treatment scores in both groups continue to improve,and the treatment group patients score was better than the controlled group,P〈0. 01,the difference was statistically significant; The two groups of patients before treatment C-reactive protein（ hs-CRP）,tumor necrosis factor（ TNF alpha）,interleukin 6,8（ IL-6,IL-8） inflammatory factor levels,P〈0. 05,4 weeks,8 weeks after treatment between groups of inflammatory factor levels were significantly decline,the treatment group was significantly lower than the controlled group,P〈0. 05,the difference was statistically significant; The total effective rate of the treatment group was 98. 00%,and the treatment satisfaction rate was 98. 00%,both higher than the controlled group 86. 00%,82. 00%,P〈0. 05,and the difference was statist
作者
万浩鹏
温桂兰
马长林
段希栋
郑燕
薛经纬
WAN Haopeng;WEN Guilan;MA Changlin(Department of Internal Medicine,Shanghai Jiading Hospital of Traditional Chinese Medicine（Shanghai 201800,China;Acute Male Area 2 of Shanghai Jiading District Mental Health Center（Shanghai 201800,China)
出处
《四川中医》
2018年第10期128-131,共4页
Journal of Sichuan of Traditional Chinese Medicine
基金
上海市嘉定区科学技术委员会科研课题(编号:2015029)
关键词
气滞血瘀型脑梗死后抑郁症
逐瘀逍遥汤
针刺
百会穴
炎性因子
Depression after cerebral infarction of Qi and blood stasis
Zhuyu Xiaoyao Decoction
Acupuncture
Buhuiacupiont
Inflammatory cytokines
